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TranscriptomicsA Common Docking (CD) Domain in Progesterone Receptor-B Links MKP3-Dependent Rapid Signaling Events to JAK/STAT Regulation of Gene Expression Required for Breast Cancer Cell Proliferation
Progesterone receptors (PRs) are critical context-dependent transcription factors required for normal uterine (PR-A) and mammary gland (PR-B) development. Progesterone is proliferative in the breast, where PR-target genes include paracrine factors that mediate mammary stem cell self-renewal. In the ...
ORGANISM(S): Homo sapiens 
2013-09-06 | E-GEOD-46850 | biostudies-arrayexpress
UnknownPotency Analysis of Mesenchymal Stromal Cells Using a Phospho-STAT Matrix Loop Analytical Approach.
Not available
S-EPMC6729138 | biostudies-literature
ProteomicsIdentifying the mechanism of platelet activation by platelet factor 4 (PF4) a.k.a CXCL4
We discovered that platelets become activated by platelet factor 4 and have looked into how this is the case. We used phosphoproteomics to identify proteins that were phosphorylated in a band on a Western blot at 95 kDa and identified phospho STAT5. We have subsequently shown that PF4 activates plat...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043558 | Pride
Human Pf4 Cxcl4 Signalling Platelets 
UnknownImmunophenotyping of peripheral eosinophils demonstrates activation in eosinophilic esophagitis.
Not available
S-EPMC4169142 | biostudies-literature
TranscriptomicsTranscription profiling of Arabidopsis mutant plants homozygous for PASTA2 vs wild type
The protein modules known as SH2 (Src-homology-2) domains are key players in the signal transduction of animals. Two questions arise: Do such modules exist in plants, and when did SH2 domains evolve? Here I show that the Arabidopsis genome contains three strong candidates for plant SH2 proteins (ref...
ORGANISM(S): Arabidopsis thaliana 
2008-02-15 | E-NASC-68 | biostudies-arrayexpress
UnknownC-type natriuretic peptide attenuates renal osteodystrophy through inhibition of FGF-23/MAPK signaling.
Not available
S-EPMC6802631 | biostudies-literature
UnknownCrizotinib Has Preclinical Efficacy in Philadelphia-Negative Myeloproliferative Neoplasms.
Not available
S-EPMC9992133 | biostudies-literature
UnknownMechanisms of Shufeng Jiedu Capsule in treating bacterial pneumonia based on network pharmacology and experimental verification.
Not available
S-EPMC11589334 | biostudies-literature
UnknownOleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway.
Not available
S-EPMC6274837 | biostudies-literature
TranscriptomicsTranscription profiling of Arabidopsis SH2 domain-containing gene PASTA mutant vs. wild type
The protein modules known as SH2 (Src-homology-2) domains are key players in the signal transduction of animals. Two questions arise: Do such modules exist in plants, and when did SH2 domains evolve? Here I show that the Arabidopsis genome contains three strong candidates for plant SH2 proteins (ref...
ORGANISM(S): Arabidopsis thaliana 
2008-06-13 | E-GEOD-5619 | biostudies-arrayexpress
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