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ProteomicsPhosphorylation dynamics in a flg22-induced, G-protein dependent network reveals the RGS1 phosphatase
The Microbe Associated Molecular Pattern flg22 is recognized in a FLAGELLIN-SENSITVE 2-dependent manner in root tip cells. Here, we show a rapid and massive change in protein abundance and phosphorylation state of the Arabidopsis root cell proteome in wildtype and a mutant deficient in heterotrimer...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2023-08-16 | MSV000092672 | MassIVE
TranscriptomicsThe yeast PP2A-CDC55 phosphatase regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4
This SuperSeries is composed of the following subset Series: GSE38565: The yeast PP2A-CDC55 phosphatase regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 [Time course 1] GSE42033: The yeast PP2A-CDC55 phosphatase regulates the transcriptional response to hy...
ORGANISM(S): Saccharomyces cerevisiae 
2012-11-06 | E-GEOD-42034 | biostudies-arrayexpress
TranscriptomicsProtein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I
Segregation of homologous maternal and paternal centromeres to opposite poles during meiosis I depends on post-replicative crossing over between homologous non-sister chromatids, which creates chiasmata and therefore bivalent chromosomes. Destruction of sister chromatid cohesion along chromosome arm...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-4791 | biostudies-arrayexpress
ProteomicsThe PP2A-2 holoenzyme orchestrates daughter cell emergence during cytokinesis in Toxoplasma gondii
Toxoplasma gondii is a significant pathogen affecting both humans and animals, with clinical symptoms primarily driven by the uncontrolled proliferation of tachyzoites. In this study, we reveal the essential role and functional plasticity of the PP2A-2 holoenzyme in orchestrating daughter cell emerg...
ORGANISM(S): Toxoplasma gondii 
2025-08-21 | PXD064226 | Pride
Toxoplasma gondii  pp2a-2 phosphatase  cytokinesis  cell division  daughter cell emergence  phosphoproteomics 
ProteomicsPhosphoproteomic Effects of Acute Depletion of PP2A Regulatory Subunit Cdc55
Protein phosphatase regulatory subunits are increasingly recognized as promising drug targets. In the absence of an existing drug, inducible degradation provides a means of predicting candidate targets. We here employed auxin-inducible degradation of S. cerevisiae PP2A regulatory subunit Cdc55 in co...
ORGANISM(S): Saccharomyces Cerevisiae 
2021-01-27 | PXD019534 | panorama
ProteomicsCytokinetic Abscission in Toxoplasma gondii is governed by Protein Phosphatase 2A and the Daughter Cell Scaffold Complex
Cytokinetic abscission is the last step of cell division during which the daughter cells physically separate through the generation of barriers in the form of new plasma membrane or cell wall. While the contractile ring is a prominent structure during cytokinesis in bacteria, fungi and animal cells,...
ORGANISM(S): Toxoplasma gondii Toxoplasma gondii 
2024-06-13 | PXD051495 | Pride
Toxoplasma gondii Cellular abscission Tachyzoites Pp2a complex Lc-esi- ms/ms 
TranscriptomicsThe yeast PP2A-CDC55 phosphatase regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 [Time course 2]
The yeast PP2A-Cdc55 Serine/Threonine phosphatase regulates transcription under certain conditions. It is required for full activation of the environmental stress response mediated by the transcription factors Msn2 and Msn4. PP2A-Cdc55 contributes to sustained nuclear accumulation of Msn2 and Msn4 a...
ORGANISM(S): Saccharomyces cerevisiae W303 
2012-11-06 | E-GEOD-42033 | biostudies-arrayexpress
ProteomicsHeLa phosphoproteome regulated by PP2A related proteins
HeLa cells were treated with siRNAs of PP2A related proteins or with okadaic acid, in triplicates. Tryptic digests of extracted proteins were analyzed using a Q Exactive mass spectrometer, before and after TiO2 phosphopeptide enrichment. Data were searched with Mascot via Proteome Discoverer. For ph...
ORGANISM(S): Homo Sapiens (human) 
2020-02-19 | PXD016102 | JPOST Repository
TranscriptomicsTargeting c-MYC by antagonizing PP2A inhibitors in breast cancer
Inhibition of SET by siRNA or SET antagonist and CIP2A by siRNA can downregulate c-MYC and c-MYC target genes. Cells were treated with a SET antagonist (1μMOP449) for 12 hours, or siRNA for 48 hours.
ORGANISM(S): Homo sapiens 
2014-05-28 | E-GEOD-58008 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human serum starvation cell lines for 24hrs, 4 cell types - TERV, TERV-ST, TERV-ST110, TERV-ASB56
Study the effects of serum starvation for 24hrs on 4 cell types - TERV, TERV-ST, TERV-ST110, TERV-ASB56.
ORGANISM(S): Homo sapiens 
2004-10-01 | E-MEXP-156 | biostudies-arrayexpress
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