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UnknownAquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis.
Not available
S-EPMC6012506 | biostudies-literature
ProteomicsStunted Procoagulant Remodelling in Montreal Platelet Syndrome Kindred with p.V1316M mutation
The Montreal Platelet Syndrome Kindred (MPS) with p.V1316M mutation (2B-VWDMPS) has been associated with chronic macrothrombocytopenia, spontaneous platelet clumping, and mucocutaneous and other bleeding which can be largely prevented by von Willebrand factor concentrate infusion. However, supplemen...
ORGANISM(S): Homo sapiens (Human) 
2023-08-22 | PXD035713 | Pride
Membrane ballooning Chloride channel clic1 2b-vwd Cytoskeletal and contractile proteins Actin Procoagulant membrane dynamics Tubulin Montreal platelet syndrome 
ProteomicsHypercoagulability and Inflammatory Markers in a Case of Congenital Thrombotic Thrombocytopenic Purpura Complicated by Fetal Demise
Patients who are diagnosed with thrombotic thrombocytopenic purpura (TTP) during pregnancy are at increased risk of maternal and fetal complications including fetal demise. We present a case of a 32-year-old G3P0 (gravida 3, para 0) who presented at 20 weeks’ gestation with a new diagnosis of congen...
ORGANISM(S): Homo sapiens (Human) 
2023-02-23 | PXD037898 | Pride
Platelets  thrombosis  procoagulant membrane dynamics  inflammatory markers  congenital  thrombotic thrombocytopenic purpura  fetal demise 
ProteomicsHeightened Procoagulation After Post-operative Thromboprophylaxis Completion in Colorectal Cancer Patients with Metastatic Bone Disease
Platelets play a pivotal role in venous thromboembolism (VTE) and in mediating colorectal cancer (CRC) progression. Still, platelets’ role in the hypercoagulability after surgical intervention for metastatic bone diseases (MBD) is ill-defined. Here, we utilised a high-resolution imaging approach to ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-23 | PXD034160 | Pride
Serum Blood Colorectal cancer Proteomics Platelets 
UnknownA novel Munc13-4/S100A10/annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells.
Not available
S-EPMC5469611 | biostudies-literature
UnknownHypercoagulability and Inflammatory Markers in a Case of Congenital Thrombotic Thrombocytopenic Purpura Complicated by Fetal Demise.
Not available
S-EPMC9737388 | biostudies-literature
ProteomicsCombined assessment of global proteome, phosphoproteome and N-terminal protein cleavage to characterize altered platelet functions in human Scott syndrome
The Scott syndrome is a rare bleeding disorder associated with a mutation in the gene encoding anoctamin-6 (TMEM16F). After stimulation of Ca2+-mobilizing agonists, syndromatic platelets show a reduced phosphatidylserine exposure and do not form membrane blebs. Given the central role of anoctamin-6 ...
ORGANISM(S): Homo sapiens (Human) 
2016-08-24 | PXD002883 | Pride
Phosphoproteome Human platelets N-terminal chafradic Lc-ms Proteome 
TranscriptomicsFibrotic Myofibroblasts Manifest Genome-Wide Derangements of Translational Control
As a group, fibroproliferative disorders of the lung, liver, kidney, heart, vasculature and integument are common, progressive and refractory to therapy. They can emerge following toxic insults, but are frequently idiopathic. Their enigmatic propensity to resist therapy and progress to organ failure...
ORGANISM(S): Homo sapiens 
2008-11-20 | E-GEOD-11196 | biostudies-arrayexpress
TranscriptomicsAngio-modulation in endothelial cells: an unexpected role of desmoglein-2 in regulating actin dynamics and its relevance to angiogenesis deregulation in systemic sclerosis
Gene expression study of DSG2 silenced human microvascular endothelial cells Affymetrix GeneChip Human Genome U133 Plus 2.0 Array were used to examine differentially expressed genes between normal microvascular endothelial cells and DSG2 silenced microvascular endothelial cells
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-21547 | biostudies-arrayexpress
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