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TranscriptomicsMicroarray to find ATF5 dependent genes in response to proteasome inhibition
Environmental stresses that disrupt protein homeostasis induce phosphorylation of eIF2, triggering repression of global protein synthesis coincident with preferential translation of ATF4, a transcriptional activator of the Integrated stress response (ISR). Depending on the extent of protein disrupti...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-43714 | biostudies-arrayexpress
TranscriptomicsMicroarray to find CHOP dependent genes in response to proteasome inhibition
Environmental stresses that disrupt protein homeostasis induce phosphorylation of eIF2, triggering repression of global protein synthesis coincident with preferential translation of ATF4, a transcriptional activator of the Integrated stress response (ISR). Depending on the extent of protein disrupti...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-43713 | biostudies-arrayexpress
ProteomicsRegulation of proteome by the proteasome upon ER stress
HeLa cells were with Tunicamycin or Thapsigargin for 8 hours in the presence or absence of MG132 or untreated. Cells were lysed by addition of HEPES 50 mM pH7.9 with 5% SDS. Proteins were precipitated with methanol/chloroforme and the proteins were resolubilized in 8 M Urea and digested with trypsin...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-04-30 | MSV000083736 | MassIVE
UnknownAn archaeal homolog of proteasome assembly factor functions as a proteasome activator.
Not available
S-EPMC3605417 | biostudies-literature
UnknownProteasome activator PA200 regulates myofibroblast differentiation.
Not available
S-EPMC6811633 | biostudies-literature
ProteomicsUncovering the Role of Proteasome Activator PA200 in Regulating the Immunoproteasome
The proteasome activator PA200 binds to the catalytic core of both standard proteasome (s20S) and the immunoproteasome (i20S); however, whether PA200 uses the same mechanisms to activate i20S remains unknown. Our cryo-EM structures of the singly- and doubly-capped i20S-PA200 complexes and in vitro a...
ORGANISM(S): Homo sapiens (Human) 
2026-05-28 | PXD075459 | Pride
Human Timstof Dia Lc-ms 
TranscriptomicsSpt6 Levels are Modulated by PAAF1 and 26S Proteasome to Regulate the HIV-1 LTR and a Subset of Cellular Genes involved in Cancer.
Effect of PAAF1 and Spt6 knock-down on gene expression. Total RNAs were extracted from HeLa-LTR-Luc cells in which PAAF1 or Spt6 had been knock down by a specific siRNA or HeLa-LTR-Luc cells that had been transfected with a control siRNA (“si Neg”). Differentially expressed genes in PAAF1 knock-down...
ORGANISM(S): Homo sapiens 
2012-05-28 | E-GEOD-32033 | biostudies-arrayexpress
UnknownStructural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis.
Not available
S-EPMC4833279 | biostudies-literature
UnknownProteasome activator Blm10 levels and autophagic degradation directly impact the proteasome landscape.
Not available
S-EPMC8039559 | biostudies-literature
ProteomicsAssembly and substrate engagement mechanism of the bacterial proteasome activator Bpa
Raw spectrum files for HDX performed to probe the temperature dependent assembly of Bpa (bacterial proteasome activator) from Mycobacterium tuberculosis.
ORGANISM(S): Mycobacterium Tuberculosis (ncbitaxon:1773) 
MSV000099239 | MassIVE
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