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ProteomicsTargeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS mutant cancers
Despite advances in the development of direct KRAS inhibitors, KRAS-mutant cancers continue to exhibit resistance to the currently available therapies. Here, we identified REGγ as a mutant KRAS-associated factor that enhances REGγ transcription through the KRAS intermediate NRF2, suggesting that the...
ORGANISM(S): Homo Sapiens 
2025-01-01 | PXD059364 |
ProteomicsNovel functions of the ubiquitin-independent proteasome system in regulating Xenopus germline development
In most species, early germline development occurs in the absence of transcription with germline determinants subject to complex translational and post-translational regulations. Here, we report for the first time that early germline development is influenced by dynamic regulation of the proteasome ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2019-04-10 | PXD013446 | Pride
Germline development Dnd1 Xenopus Oocyte-to-embryo transition Ubiquitin-independent proteasome 
GenomicsTargeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS mutant cancers
Targeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS mutant cancers
PRJNA1198056 | ENA
TranscriptomicsGLA and profiling of proteasome, Spt23 and Mga2
The proteasome can regulate transcription through proteolytic processing of transcription factors and via gene locus binding, but few targets of proteasomal regulation have been identified. Using genome-wide location analysis and transcriptional profiling in Saccharomyces cerevisiae, we have establ...
ORGANISM(S): Saccharomyces cerevisiae 
2006-02-28 | E-GEOD-4272 | biostudies-arrayexpress
Proteomics19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism
During regulated protein degradation, the 26S proteasome recognizes ubiquitinated substrates through its 19S particle and then degrades them in its 20S enzymatic core. Despite this close interdependency between proteasome subunits, we demonstrate that knockouts from different proteasome subcomplexes...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD065357 | Pride
Proteasome Mitosis Spindle Degradation Kinesin Ubiquitin 
GenomicsTargeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS mutant cancers
Despite advances in the development of direct KRAS inhibitors, KRAS-mutant cancers continue to exhibit resistance to the currently available therapies. Here, we identified REGγ as a mutant KRAS-associated factor that enhances REGγ transcription through the KRAS intermediate NRF2, suggesting that the...
ORGANISM(S): Homo sapiens 
2025-03-19 | GSE284241 | GEO
UnknownEarly recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2.
Not available
S-EPMC10418215 | biostudies-literature
UnknownEarly recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2.
Not available
S-EPMC11018354 | biostudies-literature
UnknownStructural insights into the ubiquitin-independent midnolin-proteasome pathway.
Not available
S-EPMC12088389 | biostudies-literature
UnknownProteasome-independent K63 polyubiquitination selectively regulates ATP levels and proteasome activity during fear memory formation in the female amygdala.
Not available
S-EPMC10615704 | biostudies-literature
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