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TranscriptomicsThe protein disulfide isomerase AGR2 is essential for the production of intestinal mucus
Protein disulfide isomerases (PDIs) aid protein folding and assembly by catalyzing formation and shuffling of cysteine disulfide bonds in the endoplasmic reticulum (ER). Many members of the PDI family are expressed in mammals but the roles of specific PDIs in vivo are poorly understood. A recent hom...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-12503 | biostudies-arrayexpress
ProteomicsMS analysis of an FGE-PDI complex
Multiple Sulfatase Deficiency (MSD) is a fatal, inherited lysosomal storage disorder characterised by reduced activities of all cellular sulfatases in patients. Sulfatases require a unique post-translational modification of an active site cysteine to formylglycine that is catalysed by the Formylglyc...
ORGANISM(S): Homo sapiens (Human) 
2018-07-04 | PXD009758 | Pride
Pdi Multiple sulfatase deficiency Fge 
GenomicsTreatment of Neuroblastoma Cells with Inhibitors of Protein Disulfide Isomerase Upregulates NQO1 Activity
Treatment of Neuroblastoma Cells with Inhibitors of Protein Disulfide Isomerase Upregulates NQO1 Activity
PRJNA641881 | ENA
ProteomicsFam20C interactome in the secretory pathway under ER stress
Accumulated unfolded proteins in the endoplasmic reticulum (ER) will trigger the unfolded protein response (UPR) to increase protein-folding capacity. The ER proteostasis and UPR signaling should be precisely and timely regulated. In the project, by unbiased proteomics analysis, we identify that the...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD016619 | Pride
Fam20c Pdi Er stress Phosphorylation 
ProteomicsA comprehensive set of ER PDI family members supports the biogenesis of pro-inflammatory interleukin 12 family cytokines
Cytokines of the interleukin 12 (IL-12) family are assembled combinatorially from shared alpha and beta subunits. A common theme is that human IL-12 family alpha subunits remain incompletely structured in isolation until they pair with a designate beta subunit. Accordingly, chaperones need to suppor...
ORGANISM(S): Homo sapiens (Human) 
2022-11-28 | PXD036463 | Pride
Interleukin Chaperone Protein disulfide isomerase Protein folding Genetic code expansion 
GenomicsExpression data from SH-SY5Y neuroblastoma cells treated with the protein disulfide isomerase inhibitor origamicin
Expression data from SH-SY5Y neuroblastoma cells treated with the protein disulfide isomerase inhibitor origamicin
PRJNA530280 | ENA
TranscriptomicsTreatment of Neuroblastoma Cells with Inhibitors of Protein Disulfide Isomerase Upregulates NQO1 Activity
Protein disulfide isomerase (PDI) is associated with many diseases including neurodegenerative disorders like Alzheimer’s disease and, hence, is considered a promising drug target. This study employs the two PDI inhibitors securinine and 16F16 in order to interrogate the role of PDI in the neurologi...
ORGANISM(S): Homo sapiens 
2020-12-31 | GSE153259 | GEO
UnknownMolecular bases of cyclic and specific disulfide interchange between human ERO1alpha protein and protein-disulfide isomerase (PDI).
Not available
S-EPMC3091233 | biostudies-literature
ProteomicsPDI-catalyzed oxidative protein folding mediates senescence by induction of ER-derived oxidative stress
Protein homeostasis is linked with aging and aging associated diseases. Oxidative protein folding occurs in the endoplasmic reticulum (ER) and produces H2O2 as a byproduct. The role of oxidative protein folding in human stem cells aging remains unknown. Here, we succeed to knockout protein disulfide...
ORGANISM(S): Homo sapiens (Human) 
2023-06-12 | PXD037244 | Pride
Human mesenchymal stem cells (hmscs)  hydrogen peroxide (h2o2)  oxidative 29 protein folding  protein disulfide isomerase (pdi)  senescence 
TranscriptomicsExpression data from SH-SY5Y neuroblastoma cells treated with the protein disulfide isomerase inhibitor origamicin
Protein disulfide isomerase (PDI) is associated with many diseases including neurodegenerative disorders like Alzheimer’s disease and, hence, is considered a promising drug target. In this study, we investigate the abscisic acid (ABA)-derived PDI inhibitor origamicin for its neuropharmacological pot...
ORGANISM(S): Homo sapiens 
2020-12-31 | GSE129171 | GEO
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