proteoform characterization

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Institut für Experimentelle Medizin Christian-Albrechts-Universität zu Kiel Niemannsweg 11 24105 Kiel, Germany (1)
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Department of Biostatistics and Medical Informatics and University of Wisconsin Carbone Comprehensive Cancer Center, University of Wisconsin - Madison, Madison, Wisconsin 53705, United States (1)
Molecular Biology of Reproduction and Development Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Fundació Clínic per a la Recerca Biomèdica (FCRB), Faculty of Medicine and Health Sciences, University of Barcelona Biochemistry and Molecular Genetics Service, Hospital Clínic, Barcelona (1)
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Professor, Department of Cell and Regenerative Biology Professor, Department of Chemistry Director of Mass Spectrometry Human Proteomics Program School of Medicine and Public Health University of Wisconsin-Madison (1)

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Proteoform Imaging by Combining MALDI MSI and High-sensitivity Top-down Proteomics

Spatially resolved characterization of proteoforms has great potential to significantly advance our understanding of physiological and disease mechanisms. However, it faces challenges regarding throughput and coverage. Herein, we developed a robust method for high-throughput proteoform imaging (HTPi...

ORGANISM(S): Mus Musculus

2024-12-03 | PXD058552 |

Spatially-Resolved Top-Down Proteomics of Zebrafish Brain Using Capillary Zone Electrophoresis-Tandem Mass Spectrometry

Understanding region-specific proteoform profiles in the brain is crucial for deciphering neural function and identifying potential therapeutic targets. Here, we present a comprehensive label-free quantitative top-down proteomics (TDP) analysis of distinct zebrafish brain regions using capillary zon...

ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio)

2026-06-08 | PXD070925 | Pride

Protamine characterization by top-down proteomics: Boosting proteoform identification with DBSCAN

Protamines replace histones as the main nuclear protein in sperm cells having a crucial role in compacting the paternal genome. Human spermatozoa contain the protamine 1 (P1) and the family of protamine 2 (P2) proteins. Alterations in protamine PTMs or on the P1/P2 ratio could be associated with mal...

ORGANISM(S): Homo sapiens (Human)

2021-05-13 | PXD024405 | Pride

Male infertility sperm protamine lc-ms/ms top down proteomics proteoform post-translational modifications bioinformatics dbscan.

CZE-MS/MS-based quantitative top-down proteomics reveals significant proteoform differences between healthy and Alzheimer's disease human brains

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and pathological protein aggregation. Comprehensive protein characterization of human brains of AD patients and comparison with healthy samples is critical for pursuing a better understanding of the molecular...

ORGANISM(S): Homo sapiens (Human)

2025-11-21 | PXD065459 | Pride

Top-down proteomics Human brain Proteoform Tau phosphorylation. Cze-ms/ms Alzheimer's disease

Benchmarking multiple fragmentation methods on an Orbitrap Fusion for top-down phospho-proteoform characterization

Top-down analysis of intact proteins by mass spectrometry provides an ideal platform for comprehensive proteoform characterization, in particular, for the identification and localization of post-translational modifications (PTM) co-occurring on a protein. One of the main bottlenecks in top-down prot...

ORGANISM(S): Homo sapiens (Human)

2015-07-16 | PXD001845 | Pride

Fragmentation Bora Ethcd Top down proteomics Phosphorylation Proteoform Orbitrap fusion

Evaluation of cleavable crosslinking for characterization of proteoform structural differences by top-down mass spectrometry

Cleavable crosslinking has traditionally been employed in bottom-up mass spectrometry to elucidate protein structure and protein-protein interactions through identification of peptides bearing characteristic mass adducts. Here, we demonstrate the application of cleavable crosslinking in top-down mas...

ORGANISM(S): Homo Sapiens (human) Equus Caballus

2026-01-17 | PXD073175 | JPOST Repository

Mass spectrometry-based top-down proteomics in nanomedicine: proteoform-specific measurement of protein corona

Conventional mass spectrometry (MS)-based bottom-up proteomics (BUP) analysis of protein corona [i.e., an evolving layer of biomolecules, mostly proteins, formed on the surface of nanoparticles (NPs) during their interactions with biomolecular fluids] enabled nanomedicine community to partly identif...

ORGANISM(S): Homo sapiens (Human)

2024-10-15 | PXD050779 | Pride

Protein corona Top-down proteomics Nanomedicine Plasma Proteoform

Intact Mass Proteomics Using a Proteoform Atlas.

Not available

S-EPMC12045104 | biostudies-literature

Proteoform-Selective Imaging of Tissues Using Mass Spectrometry.

Not available

S-EPMC9276647 | biostudies-literature

Integrated top-down and bottom-up mass spectrometry enables precise characterization of proteoforms and their post-translational modifications within the protein corona

Precise characterization of proteins and proteoforms within the protein corona is essential for developing safer and more effective nanomedicines for diagnostic and therapeutic applications. Although the protein corona phenomenon has been recognized in nanomedicine for nearly two decades, the applic...

ORGANISM(S): Homo sapiens (Human)

2026-05-14 | PXD077545 | Pride

Bup Peptide Ptm Proteoform Protein corona Tdp

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