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ProteomicsQuantitative subcellular proteomics using SILAC reveals enhanced metabolic buffering in ground state pluripotency
The ground state of pluripotency is defined as a minimal unrestricted state as present in the Inner Cell Mass (ICM). Mouse embryonic stem cells (ESCs) grown in a defined serum-free medium with two kinase inhibitors (‘2i’) reflect this state, whereas ESCs grown in the presence of serum (‘serum’) shar...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-07 | PXD009217 | Pride
Embryonic stem cells Naïve pluripotency Metabolism Silac 
UnknownRedox proteomic insights into involvement of clathrin-mediated endocytosis in silver nanoparticles toxicity to Mytilus galloprovincialis.
Not available
S-EPMC6205585 | biostudies-literature
UnknownHsp70-associated chaperones have a critical role in buffering protein production costs.
Not available
S-EPMC5788500 | biostudies-literature
UnknownApplication of fluorescence two-dimensional difference in-gel electrophoresis as a proteomic biomarker discovery tool in muscular dystrophy research.
Not available
S-EPMC4009800 | biostudies-literature
ProteomicsDivergent proteome tolerance against gain and loss of chromosome arms
How aneuploid cells tolerate chromosome arm gains or losses remains an open question. Using an isogenic human lung cell model with either 3p loss or 3q gain, combined with quantitative mass spectrometry and isotopic labeling, we reveal distinct proteostasis mechanisms for gain- and loss-type aneuplo...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD062437 | Pride
Proteostasis  gain and loss  chromosome 3  lung cancer  proteomic buffering : aneuploidy  proteomics  dynamic silac  protein degradation  protein synthesis 
ProteomicsIntegrated Multilayer Omics Reveals the Genomic, Proteomic and Metabolic Influences of the Histidyl Dipeptides on Heart
Histidyl dipeptides, such as carnosine, present in a micro-millimolar ranges in the heart, are synthesized via the enzyme carnosine synthase (Carns). These dipeptides facilitate glycolysis by proton buffering, form conjugates with reactive aldehydes, such as acrolein, and attenuate ischemia and repe...
ORGANISM(S): Mus <genus> 
2021-12-25 | PXD030647 |
UnknownProteomic profiling of impaired excitation-contraction coupling and abnormal calcium handling in muscular dystrophy.
Not available
S-EPMC10078611 | biostudies-literature
UnknownIntegrated Multilayer Omics Reveals the Genomic, Proteomic, and Metabolic Influences of Histidyl Dipeptides on the Heart.
Not available
S-EPMC9333374 | biostudies-literature
UnknownProteomic Analysis of the Differential Response of <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i> to <i>Lacticaseibacillus rhamnosus</i> Cell-Free Supernatant and Lactic Acid.
Not available
S-EPMC12730115 | biostudies-literature
OtherDivergent proteome tolerance against gain and loss of chromosome arms
How aneuploid cells tolerate chromosome arm gains or losses remains an open question. Using an isogenic human lung cell model with either 3p loss or 3q gain, combined with quantitative mass spectrometry and isotopic labeling, we reveal distinct proteostasis mechanisms for gain- and loss-type aneuplo...
ORGANISM(S): Homo sapiens 
2026-03-25 | GSE293644 | GEO
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