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ProteomicsNetwork pharmacology and multi-omics validation of the Jianpi-Yishen formula in the treatment of chronic kidney disease
This study utilized network pharmacology, RNA sequencing (RNA-seq), and metabolic analyses using in vivo and in vitro models to investigate the impact of the JPYS formula on inflammation and the immune system. Specifically, the study focused on macrophage polarization and metabolic changes that may ...
ORGANISM(S): Mus Sp. 
2025-01-10 | PXD059614 |
ProteomicsLC-MS/MS data of Tinospora cordifolia
Tinospora cordifolia has been used for thousands of years to treat various health conditions, including neurodegenerative diseases. The study aimed to elucidate the mechanism of action and protein targets of T. cordifolia in the context of Alzheimers disease through untargeted metabolomics and netwo...
ORGANISM(S): Tinospora Cordifolia (ncbitaxon:285590) 
2024-11-04 | MSV000096283 | MassIVE
ProteomicsSystems pharmacology using mass spectrometry identifies critical response nodes in prostate cancer
Pelleted non-perturbed LNCaP cells were lysed using LysisBuffer (8 M urea, 0.1 M ammonium bicarbonate, 0.1 % RapiGest) and nucleic acids sheared using sonication.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-22 | MSV000081956 | MassIVE
ProteomicsDegraders of the dengue virus capsid protein exhibit differentiated pharmacology relative to capsid inhibitors
Due to the limited size of viral genomes, most viral proteins are multifunctional; yet most direct-acting antivirals are designed as single-function inhibitors. The dengue virus (DENV) capsid protein serves as a building block for new virions while also interacting with multiple host factors to remo...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD063557 | Pride
Degrader Dengue Capsin Virus Crbn Chemical biology Protac Ubiquitin 
ProteomicsProteomics and network pharmacology of Ganshu Nuodan capsules in the prevention of alcoholic liver disease
A mouse model of acute alcohol liver disease (ALD) induced by intragastric administration of 50% alcohol was used to evaluate the hepatoprotective effect of Ganshu Nuodan. The chemical constituents of Ganshu Nuodan were comprehensively identified by UPLC-QTOF/MS, and then its pharmacodynamic materia...
ORGANISM(S): Mus Musculus 
2023-09-08 | PXD045221 |
TranscriptomicsTranscriptomics profiling of ccc_R08 for mechanism-of-action investigation with forward pharmacology
To investigate the mode of action of ccc_R08, a first-in-class orally available HBV cccDNA inhibitor, we designed and implemented two orthogonal and complementary approaches: a forward pharmacology approach and a reverse pharmacology approach. Bioinformatics analysis integrating biological knowledge...
ORGANISM(S): Homo sapiens 
2022-12-30 | GSE214515 | GEO
TranscriptomicsDeciphering risperidone-induced lipogenesis by network pharmacology and molecular validation
Risperidone is an atypical antipsychotic that can cause substantial weight gain. The pharmacological targets and molecular mechanisms related to risperidone-induced lipogenesis (RIL) remain to be elucidated. Therefore, network pharmacology and further experimental validation were undertaken to explo...
ORGANISM(S): Mus musculus 
2022-05-11 | GSE198053 | GEO
TranscriptomicsIntegrative Pharmacology Strategy Powers the Delineation of the Main Active Components and Exploration the Underlying Mechanism of WBT Acting on Rheumatoid Arthritis
Wang Bi Tablet (WBT) exhibits effective power in clinic during the treatment of rheumatoid arthritis (RA) in China. We aimed to employ the “integrative pharmacology strategy”, including rapid analysis of chemical composition, pharmacological experiment, and network pharmacology analysis, to delineat...
ORGANISM(S): Mus musculus 
2021-05-10 | GSE165272 | GEO
TranscriptomicsPrediction of VEGF-C as a key target of pure total flavonoids from Citrus against NAFLD in mice via network pharmacology
Pure total flavonoids from Citrus (PTFC) effectively reduce the symptoms of non-alcoholic fatty liver disease (NAFLD). Our previous microarray analysis uncovered the alterations of important signaling pathways in the treatment of NAFLD with PTFC. However, the underlying core genes that might be targ...
ORGANISM(S): Mus musculus 
2019-03-27 | GSE128850 | GEO
TranscriptomicsIntegrative Pharmacology Powers the Active Components Detection and Mechanism Exploration of Wang Bi Granules Acting on Rheumatoid Arthritis
Wang Bi Granule (WBG), composed of 16 botanical drugs and 1 animal drug, is clinically used to treat “Wang Bi” syndrome, which mainly refers to later rheumatoid arthritis (RA) in modern medicine, as well as ankylosing spondylitis, tuberculous arthritis, and Kashin-Beck disease characterized by joint...
ORGANISM(S): Mus musculus 
2022-06-01 | GSE181156 | GEO
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