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TranscriptomicsMolecular effects of capsaicin on human gingival epithelial cells
In order to explain the molecular mechanisms of capsaicin-induced proliferation of gingival epithelial cells (GECs), a microarray analysis was performed. Several cell proliferation related genes were significantly up-regulated. These data suggest that TRPV1 signaling in GEC may induce transcriptiona...
ORGANISM(S): Homo sapiens 
2014-05-17 | E-GEOD-57759 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human gastric cancer cell line AGS treated with Capsaicin against DMSO
Capsaicin has previously been demonstrated to exhibit anti-tumor effect in various cancer type. However, the deep biological function and molecular mechanism of capsaicin was still uncertain. In this research, we used high-throughput RNA sequencing to unveil the potential biological function of caps...
ORGANISM(S): Homo sapiens 
2024-11-01 | E-MTAB-14511 | biostudies-arrayexpress
TranscriptomicsNociceptor HDAC4 regulates inflammatory pain
Transcriptional alterations are characteristic of persistent pain states but the key regulators remain elusive. Using a conditional knockout (cKO) strategy in mice we sought to determine whether loss of the transcriptional co-repressor histone deacetylase four (HDAC4) would have implications for sen...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-62405 | biostudies-arrayexpress
ProteomicsDegraders of the dengue virus capsid protein exhibit differentiated pharmacology relative to capsid inhibitors
Due to the limited size of viral genomes, most viral proteins are multifunctional; yet most direct-acting antivirals are designed as single-function inhibitors. The dengue virus (DENV) capsid protein serves as a building block for new virions while also interacting with multiple host factors to remo...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD063557 | Pride
Degrader Dengue Capsin Virus Crbn Chemical biology Protac Ubiquitin 
ProteomicsProteomic and phosphoproteomic analyses reveal the biological perturbations caused by capsaicin
In this study, we established a highly effective proteomic strategy that is broadly applicable for investigating the mechanisms of action of chemicals on the basis of pressure cycling technology (PCT). We conducted comprehensive proteomic and phosphoproteomic analyses to investigate the effects of c...
ORGANISM(S): Homo Sapiens 
2024-11-10 | PXD057732 |
MetabolomicsHigh-dose capsaicin exacerbates uveitis by disrupting intestinal ho-meostasis and upregulating IL-17
Purpose: To determine whether capsaicin (CAP) exacerbates experimental autoimmune uveitis (EAU) and whether this effect is associated with impaired intestinal homeostasis, gut microbiota re-modeling, and altered metabolic profiles. Methods: An EAU mouse model was used to evaluate the dose-dependent ...
2026-07-23 | MTBLS15144 | MetaboLights
MetabolomicsCapsaicin ameliorates glycemic levels via gut microbiota-derived 5-aminolevulinic acid in mice

Background: Capsaicin, a natural alkaloid in chili peppers, regulates glycemic levels, however, its mechanisms and therapeutic potential remain unclear. This study aimed to elucidate the role of gut microbiota and their metabolites in mediating capsaicin’s glycemic regulatory effects. We conducte...

2025-06-13 | MTBLS12575 | MetaboLights
MetabolomicsEvaluation of ambient mass spectrometry tools for assessing inherent postharvest pepper quality

Horticulturists are interested in evaluating how cultivar, environment, or production system inputs can affect postharvest quality. Ambient mass spectrometry approaches enable analysis of minimally processed samples under ambient conditions and offer an attractive high-throughput alternative for ...

2022-03-04 | MTBLS2587 | MetaboLights
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