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ProteomicsCathepsin B Promotes Aβ Proteotoxicity by Modulating Aging Regulating Mechanisms
While the activities of certain proteases promote proteostasis and prevent neurodegeneration-associated phenotypes, the protease cathepsin B (CTSB) enhances proteotoxicity in Alzheimer’s disease (AD) model mice, and its levels are elevated in brains of AD patients. How CTSB exacerbates the toxicity ...
ORGANISM(S): Caenorhabditis elegans 
2024-09-03 | PXD045531 | Pride
Proteotoxicity Aging Cathepsin b Neurodegeneration 
ProteomicsCathepsin B Promotes Aβ Proteotoxicity by Modulating Aging Regulating Mechanisms
While the activities of certain proteases promote proteostasis and prevent neurodegeneration-associated phenotypes, the protease cathepsin B (CTSB) enhances proteotoxicity in Alzheimer’s disease (AD) model mice, and its levels are elevated in brains of AD patients. How CTSB exacerbates the toxicity ...
ORGANISM(S): Caenorhabditis elegans 
2024-09-04 | PXD045561 | Pride
Cathepsin b C. elegans Aβ proteotoxicity 
ProteomicsProteotoxicity caused by perturbed protein complexes underlies hybrid incompatibility
Dobzhansky-Muller incompatibilities represent a major driver of reproductive isolation between species. They are caused when two or more interacting components encoded by alleles from different species cannot function properly when mixed. At incipient stages of speciation, complex incompatibilities ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-07-05 | PXD028358 | Pride
Epistasis Protein complex Proteotoxicity Proteostasis Speciation Genetic incompatibility 
GenomicsA Short Peptide Protects from Age-Onset Proteotoxicity
A Short Peptide Protects from Age-Onset Proteotoxicity
PRJNA962043 | ENA
GenomicsCathepsin B Promotes Aβ Proteotoxicity by Modulating Aging Regulating Mechanisms
Cathepsin B Promotes Aβ Proteotoxicity by Modulating Aging Regulating Mechanisms
PRJNA974377 | ENA
ProteomicsIsoflurane Aggravates Pre-Existing Proteotoxicity in Adult Nematodes by Suppressing Mitochondrial Fitness
Post operative delirium (POD) is an acute complication characterized by fluctuating attention and confusion which may develop and persist into cognitive decline. POD is most commonly observed in elderly patients, particularly those with preexisting cognitive impairments. Isoflurane, as a widely used...
ORGANISM(S): Caenorhabditis elegans 
2025-09-13 | PXD054547 | Pride
Proteostasis Proteotoxicity Mitochondria Aging Volatile anesthetics Delirium C. elegans 
GenomicsIsoflurane Aggravates Pre-Existing Proteotoxicity in Adult Nematodes by Modulating Mitophagy
Isoflurane Aggravates Pre-Existing Proteotoxicity in Adult Nematodes by Modulating Mitophagy
PRJNA1139128 | ENA
GenomicsCytoplasmic proteotoxicity regulates HRI-dependent phosphorylation of eIF2a via the Hsp70-Bag3 module.
Cytoplasmic proteotoxicity regulates HRI-dependent phosphorylation of eIF2a via the Hsp70-Bag3 module.
PRJNA719638 | ENA
UnknownDeubiquitinase JOSD1 tempers hepatic proteotoxicity.
Not available
S-EPMC11405666 | biostudies-literature
ProteomicsCathepsin B Promotes Aβ Proteotoxicity by Modulating Aging Regulating Mechanisms
While the activities of certain proteases promote proteostasis and prevent neurodegeneration-associated phenotypes, the protease cathepsin B (CTSB) enhances proteotoxicity in Alzheimer’s disease (AD) model mice, and its levels are elevated in brains of AD patients. How CTSB exacerbates the toxicity ...
ORGANISM(S): Caenorhabditis elegans 
2024-09-03 | PXD045565 | Pride
Cathepsin activity Neurodegeneration C.elegans 
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