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MetabolomicsThe pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication

BACKGROUND: In all living organisms, DNA replication is exquisitely regulated in a wide range of growth conditions to achieve timely and accurate genome duplication prior to cell division. Failures in this regulation cause DNA damage with potentially disastrous consequences ...

2022-04-19 | MTBLS4415 | MetaboLights
GenomicsPyruvate Kinase M2 Regulates Photoreceptor Neuroprotection
Pyruvate Kinase M2 Regulates Photoreceptor Neuroprotection
PRJNA1125309 | ENA
ProteomicsPyruvate kinase M2 modification by a lipid peroxidation byproduct acrolein contributes to kidney fibrosis
This study used a proteomic approach with an anti-Acr-PC antibody followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis to identify several acrolein-modified protein targets. Among these protein targets, pyruvate kinase M2 (PKM2) was found to be modified by acrolein at Cys35...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD040335 | Pride
Renal fibrosis  acrolein  pyruvate kinase m2  hypoxia-inducible factor 1-alpha  hydralazine  carnosine. 
ProteomicsSUMOylation disassembles the tetrameric pyruvate kinase M2 to block myeloid differentiation of leukemia cells
Leukemia arises from blockage of the differentiation/maturation of hematopoietic progenitor cells at different stages with uncontrolled proliferation of leukemic cells. However, the signal pathways that block cell differentiation remain unclear. Herein we found that SUMOylation of the M2 isoform of ...
ORGANISM(S): Homo Sapiens 
2020-12-26 | PXD023317 |
MetabolomicsTargeted metabolomic analysis in hepatic extracts, serum, and urine of female mice gavaged with TCDD every 4 days for 28 days
TCDD is an environmental contaminant that elicits a number of hepatic effects including fat accumulation, inflammation, and fibrosis that can progress to hepatocellular carcinoma. RNA-Seq and targeted metabolomics were integrated with complementary dioxin response element (DRE) location and aryl hyd...
2017-02-02 | MTBLS225 | MetaboLights
ProteomicsGPC3-mediated metabolic rewiring of diabetic mesenchymal stromal cells enhances their cardioprotective functions via pyruvate kinase M2 activation
Mesenchymal stromal cells (MSC) are promising stem cell therapy for treating cardiovascular and other degenerative diseases. Diabetes affects the functional capability of MSC and impedes cell-based therapy. Despite numerous studies, the impact of diabetes on MSC myocardial reparative activity, metab...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-08-21 | MSV000095670 | MassIVE
ProteomicsHydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2
Cancer cells reprogram their glucose metabolic pathway from oxidative phosphorylation toward aerobic glycolysis. Pyruvate kinase M2 (PKM2), which converts phosphoenolpyruvate (PEP) to pyruvate, is considered the rate-limiting enzyme involved in cancer glucose metabolism. By reducing PKM2 enzyme acti...
ORGANISM(S): Homo sapiens (Human) 
2024-07-09 | PXD044925 | Pride
Glucose metabolism Pkm2 Lc-ms Oligomerization Sulfhydration Hydrogen sulfide 
TranscriptomicsExpression data from PKM1 or PKM2 expressing mouse embryonic fibroblasts.
We profiled global gene expression for two separate lines of mouse embryonic fibroblasts and find that deletion of PKM2 and expression of PKM1 does not alter global gene expression profiles. We used microarrays to futher characterize the effects of PKM1 expression compared to PKM2 expression on glob...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-60499 | biostudies-arrayexpress
TranscriptomicsPyruvate Kinase M2 Regulates Photoreceptor Neuroprotection
Pyruvate kinase M2 (PKM2) is a glycolytic enzyme and transcription co-activator that is expressed in cancer cells. Its role in tumor metabolism is not definitively established, but investigators have suggested that regulation of PKM2 activity can cause accumulation of glycolytic intermediates and in...
ORGANISM(S): Mus musculus 
2026-06-19 | GSE270134 | GEO
ProteomicsProteomic profiling of mouse brain pyruvate kinase binding proteins: a hint for moonlighting functions of PKM1?
Affinity based proteomic profiling is widely used for identification of proteins involved in for-mation of various interactomes. Pyruvate kinase (PK), a classical glycolytic enzyme catalyzing the last step of glycolysis, exists in four isoforms, one of which, PKM2; pyruvate kinase muscle isoform M2 ...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD041321 | Pride
Pyruvapyruvate kinase  pyruvate kinase isoforms  pkm  non-canonical moonlighting functions  pkm-binding proteins  interactomete kinase  pyruvate kinase isoforms  pkm  non-canonical moonlighting functions  pkm-binding proteins  interactome 
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