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ProteomicsPyrin oligomerization nucleates antiviral IFI16 sensing of herpesvirus DNA
The formation of multimerized protein assemblies has emerged as a core component of immune signal amplification, yet the biochemical basis of this phenomenon remains unclear for many mammalian proteins within host defense pathways. The interferon-inducible protein 16 (IFI16) is a viral DNA sensor th...
ORGANISM(S): Homo sapiens (Human) 
2019-07-10 | PXD014349 | Pride
Ifi16 Ip-ms Dna sensing Hsv-1 Oligomerization 
ProteomicsOligomerization of PRMT1 Regulated RNA-Binding Protein Cascade Promotes Pancreatic Ductal Adenocarcinoma
PRMT1 is the predominant type I protein arginine methyltransferase responsible for generating monomethylarginine and asymmetric dimethylarginine (MMA and ADMA) in various protein substrates. It regulates numerous biological processes, including RNA metabolism, mRNA splicing, DNA damage repair, and c...
ORGANISM(S): Homo Sapiens 
2025-03-12 | PXD061743 |
ProteomicsFAM134B oligomerization drives ER membrane scission for ER-phagy
ER degradation by selective autophagy (ER-phagy) is crucial for ER homeostasis. However, it remains unclear how ER scission is regulated for subsequent autophagosomal sequestration and lysosomal degradation. Here, we show that oligomer formation of FAM134B (also referred to as reticulophagy regulato...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD016661 | Pride
Er-phagy  fam134b oligomerization  membrane fragmentation  er stress  camk2b 
GenomicsControl of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
PRJNA742124 | ENA
GenomicsDifferential oligomerization regulates PHF13 chromatin function and affinity [ATAC-seq]
Differential oligomerization regulates PHF13 chromatin function and affinity [ATAC-seq]
PRJNA1223399 | ENA
GenomicsSpatiotemporal Control of InflammatoryLytic Cell Death Through Optogenetic Induction of RIPK3 Oligomerization
Spatiotemporal Control of InflammatoryLytic Cell Death Through Optogenetic Induction of RIPK3 Oligomerization
PRJNA1118192 | ENA
GenomicsDifferential oligomerization regulates PHF13 chromatin function and affinity [RNA-seq]
Differential oligomerization regulates PHF13 chromatin function and affinity [RNA-seq]
PRJNA1223390 | ENA
GenomicsN4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
PRJNA698568 | ENA
GenomicsAu18(L-NIBC)14 targets ASC oligomerization for autoimmune disease treatment
Au18(L-NIBC)14 targets ASC oligomerization for autoimmune disease treatment
PRJNA1250400 | ENA
GenomicsA SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor
Multicellular organisms develop new structures by initiating specific gene regulatory programs through coordinated changes at the transcriptional and chromatin levels. Master transcription factors orchestrate such global changes but the underlying molecular mechanisms remain unclear. Here we focus o...
ORGANISM(S): Arabidopsis thaliana 
2016-04-08 | GSE64245 | GEO
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