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Proteomics17β-Estradiol Delivered in Eye Drops: A Proteomics Study Focusing on the Rat Retina
Five ovariectomized (OVX) Brown Norway rats (Charles Rivers Laboratories, Wilmington, DE, USA) weighing 200-250 g received 10 µL of 17β-estradiol (E2) eye drops once daily in both eyes for three weeks [20]. The eye drops contained 0.1% (w/v) E2 in saline vehicle containing 20% (w/v) 2-hydroxypropyl-...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-27 | PXD010851 | Pride
Retina Datadependent acquisition Rat Label-free Estradiol 
ProteomicsRat retina and optic nerve LC-MS/MS
Various retinal disorder such as glaucomatous, retinal ischemia reperfusion, and traumatic optic neuropathy, are involved in the pathogenesis of neurodegeneration via glutamate exicitotoxicity. However, the proteomic characteristics and modulation of the neural-microenvironment with NMDA-induced neu...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-12-30 | PXD022729 | Pride
Rat Optic nerve Retina Lc-ms/ms 
ProteomicsNeuroretinal-derived caveolin-1 promotes endotoxin-induced inflammation in the murine retina
Chronic ocular inflammation is associated with many retinal degenerative diseases that result in vision loss. The immune-privileged environment and complex organization of retinal tissue allow for the retina’s essential role in visual function processes, yet confound inquiries into cell-specific inf...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD016872 | Pride
Caveolin-1  caveolin  caveolae  inflammation  neural retina  retina  retinal degeneration  immune response 
ProteomicsRat retina and optic nerve LC-MS/MS
Various retinal disorder such as glaucomatous, retinal ischemia reperfusion, and traumatic optic neuropathy, are involved in the pathogenesis of neurodegeneration via glutamate exicitotoxicity. However, the proteomic characteristics and modulation of the neural-microenvironment with NMDA-induced neu...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-12-30 | PXD022466 | Pride
Rat Optic nerve Retina Lc-ms/ms 
ProteomicsFirst identification of ITM2B interactome in the human retina
ITM2B is a type II ubiquitous transmembrane protein which role remains unclear. ITM2B mutations have been associated with different disorders: mutations leading to longer mutant proteins have been reported in two distinct Alzheimer-like autosomal dominant disorders with early-onset progressive demen...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020088 | Pride
Ap-ms Human Itm2b Retina Interactome 
ProteomicsLabel-free semi-quantitative proteome profiling of retinas at P5 of Wild type and Cfap418-/- mice
Label-free semi-quantitative proteome profiling of retinas at P5 of Wild type and Cfap418-/- mice
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-04-29 | MSV000089334 | MassIVE
ProteomicsRetina-Targeted 17β-Estradiol by the DHED Prodrug Rescues Visual Function and Actuates Neuroprotective Protein Net-works after Optic Nerve Crush in a Rat Model of Surgical Menopause. Katalin Prokai-Tatrai, Khadiza Zaman, Ammar Kapic, Kelleigh Hogan , Gabriela Sanchez-Rodriguez, Anna E. Silverio Vien Nguyen , Laszlo Prokai and Andrew J. Feola
The association between 17β-estradiol (E2) deprivation, seen in menopause and a risk for devel-oping glaucoma, has been shown. Thus, exogenous supplementation of E2 may protect against retinal ganglion cell (RGC) degradation and vision loss. Here, we investigated the utility of topical 10β,17β-dihyd...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-07 | PXD059520 | Pride
Bioinformatics  dhed  estrogen  glaucoma  menopause  optic nerve crush  optomotor response  protein–protein interaction networks  quantitative label-free retina proteomics 
ProteomicsThe interactome of Complexin 4-SNARE complexes in mouse retina
Complexin (Cplx)3 and Cplx4, SNARE-complex-regulators of the Cplx family, have been proposed to be involved in the light adaptation of ribbon synapses by limiting synaptic vesicle (SV) recruitment and fusion, but how this Cplx effect is exerted is unknown. Focusing on light adaptation of rod photore...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-20 | PXD047206 | Pride
Mouse retina Ribbon synapses G protein Label-free quantification Complexin 4 Data-independent acquisition 
ProteomicsProteome analysis of the retina from RhoQ344X/+ mouse
Retinal proteomes from wild-type and RhoQ344X mutant mice at postnatal day 35 were analyzed by label-free quantitative proteomics to understand proteomic change caused by the rhodopsin mutation.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-11-08 | MSV000093339 | MassIVE
Unknown17β-Estradiol Delivered in Eye Drops: Evidence of Impact on Protein Networks and Associated Biological Processes in the Rat Retina through Quantitative Proteomics.
Not available
S-EPMC7076522 | biostudies-literature
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