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UnknownComparative structural analysis provides new insights into the function of R2-like ligand-binding oxidase.
Not available
S-EPMC9314684 | biostudies-literature
UnknownEther cross-link formation in the R2-like ligand-binding oxidase.
Not available
S-EPMC6060897 | biostudies-literature
UnknownAssembly of a heterodinuclear Mn/Fe cofactor is coupled to tyrosine-valine ether cross-link formation in the R2-like ligand-binding oxidase.
Not available
S-EPMC6399176 | biostudies-literature
ProteomicsLCMS quantification of internal crosslink in WT and G68L mutant R2lox proteins from Geobacillus kaustophilus.
A heterobimetallic Mn/Fe cofactor is found in the R2 subunit of class Ic ribonucleotide reductases (R2c) and R2-like ligand-binding oxidases (R2lox). Although the protein-derived metal ligands are the same in both groups of proteins, the connectivity of the two metal ions and the chemistry each cofa...
ORGANISM(S): Geobacillus kaustophilus 
2019-10-31 | PXD015549 | Pride
Ferritin  metalloprotein  ribonucleotide reductase  r2-like ligand-binding oxidase  r2lox  crosslink 
UnknownKey Structural Motifs Balance Metal Binding and Oxidative Reactivity in a Heterobimetallic Mn/Fe Protein.
Not available
S-EPMC7390604 | biostudies-literature
UnknownOxoiron(IV) complexes as synthons for the assembly of heterobimetallic centers such as the Fe/Mn active site of Class Ic ribonucleotide reductases.
Not available
S-EPMC5756673 | biostudies-literature
MetabolomicsSMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical features of these alterations and the age of onset in the brain and peripheral ...

2023-11-27 | MTBLS8784 | MetaboLights
UnknownSpontaneous Formation of an Fe/Mn Diamond Core: Models for the Fe/Mn Sites in Class 1c Ribonucleotide Reductases.
Not available
S-EPMC8997264 | biostudies-literature
TranscriptomicsRNA-seq analysis of astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape
The host response of the primary intestinal epithelium to human astrovirus (HAstV infection has not been elucidated to date. In order to characterize the global effects of AstV infection on human intestinal tissue, we performed transcriptional profiling of VA1-infected human intestinal enteroids (HI...
ORGANISM(S): Homo sapiens 
2019-10-31 | E-MTAB-8527 | biostudies-arrayexpress
TranscriptomicsLongitudinal scRNAseq profiling of memory B cells in mRNA vaccinated individuals post BA.1-breakthrough infection
Memory B cells play a fundamental role in host defenses against viruses. This dataset aimed at understanding the recruitment and remodeling of the memory B cell repertoire in the context of BA.1-breakthrough infection in BNT162b2 mRNA vaccinated individuals. All four donors enrolled in the study had...
ORGANISM(S): Homo sapiens 
2023-08-15 | E-MTAB-12651 | biostudies-arrayexpress
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