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MetabolomicsFerritin aggregation: A neotype and universal engager for CAR T cell avidity engineering against diverse refractory leukemias

Introduction: Primary liver cancer remains the third leading cause of global cancer-related mortality, with hepatocellular carcinoma (HCC) constituting the predominant histological subtype. The development of malignant ascites in advanced HCC patients signifies metastatic progression and portends...

2025-12-24 | MTBLS13569 | MetaboLights
ModelsMasison2022 - Cellular ferritin iron storage
This is a small model of ferritin iron sequestration kinetics. The model’s parameter values were determined from published kinetic and binding experiments and the model was validated against independent data not used in its construction. Beyond its utility to investigate properties of ferritin iron ...
2023-02-07 | MODEL2211030001 | BioModels
ModelsMasison2022 - Liver Iron Metabolism with updated ferritin
This is a new version of a liver iron model (original from Mitchell 2013 BIOMD0000000498) with updated kinetics of ferritin iron storage. It uses MODEL2211030001 as a substitute for the original ferritin reactions.
2023-02-07 | MODEL2211030002 | BioModels
ProteomicsSerum H-ferritin to Ferritin ratio as a biomarker of HLH in critically ill patients with hyperferritinemia
Ferritin is a sensitive screening parameter to diagnose hemophagocytic lymphohistiocytosis in critically ill patients but lacks specificity. Ferritin is composed of 24 subunits with 2 types of peptide chains: light (FeL) or heavy (FeH). The proportion of H subunit is suggested to increase during hyp...
ORGANISM(S): Homo sapiens (Human) 
2026-03-06 | PXD065102 | Pride
Lc-msms Human Ferritin Serum 
MetabolomicsFatal COVID-19 pulmonary disease involves ferroptosis.

SARS-CoV-2 infection causes severe pulmonary manifestations, with poorly understood mechanisms and limited treatment options. Hyperferritinemia and disrupted lung iron homeostasis in COVID-19 patients imply that ferroptosis, an iron-dependent cell death, may occur. Immunostaining and lipidomic an...

2024-07-11 | MTBLS3107 | MetaboLights
GenomicsTranstriptome analysis of bone marrow-derived neutrophils after ferritin injection
Transtriptome analysis of bone marrow-derived neutrophils after ferritin injection
PRJNA744532 | ENA
TranscriptomicsTranstriptome analysis of bone marrow-derived neutrophils after ferritin injection
How ferritin regulates neutrophil leukocyte function remains unknown. To address this question, we injected mice with ferritin. bone marrow-derived neutrophils (BMDN) were isolated by density gradient centrifugation. Then we displayed RNA-seq of isolated BMDNs.
ORGANISM(S): Mus musculus 
2021-07-09 | GSE179679 | GEO
ProteomicsFerritin-mediated iron detoxification mediates hypothermia survival in Caenorhabditis elegans and murine neurons.
How animals rewire cellular programs to survive cold is a fascinating problem with potential biomedical implications, ranging from emergency medicine to space travel. Studying a hibernation-like response in the free-living nematode Caenorhabditis elegans, we uncovered a regulatory axis that enhances...
ORGANISM(S): Caenorhabditis elegans 
2022-10-14 | PXD034794 | Pride
Ferritin heavy chain Ferrous iron Foxo Ets-4 Neuroprotection Ferroxidase Daf-16 Fth1 Cold Ftn-1 Pqm-1 Ros Antioxidant Hibernation Iron Fe2+ Hypothermia 
TranscriptomicsBulk RNA-seq of the human malaria parasite Plasmodium falciparum 3D7 cultured under different iron conditions
Background: Host iron deficiency is protective against severe malaria as the human malaria parasite Plasmodium falciparum depends on free iron from its host to proliferate. Due to the absence of transferrin, ferritin, ferroportin, and a functional heme oxygenase, the parasite’s essential pathways of...
ORGANISM(S): Plasmodium falciparum 
2024-04-08 | E-MTAB-13411 | biostudies-arrayexpress
Genomics
Dendrorhynchus zhejiangensis Ferritin
PRJNA668446 | ENA
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