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MetabolomicsEffects of a Compound from the Group of Substituted Thiadiazines with Hypothermia Inducing Properties on Brain Metabolism in Rats, a Study In Vivo and In Vitro
The aim of the present study was to examine how administration of a compound of 1,3,4-thiadiazine class 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine hydrobromide (L-17) with hypothermia inducing properties affects the brain metabolism. The mechanism by which L-17 induces hypothermia is unknown; it may...
2018-07-27 | MTBLS482 | MetaboLights
TranscriptomicsTranscription profiling of human actute monocytic leukemia cell line THP-1 cells incubated at 37 or 32 degrees C for 24h reveals moderate hypothermia produces substantial changes in cellular gene expression, in categories potentially of importance to systemic function.
Background: Moderate hypothermia (32oC for 12 – 72 hours) has therapeutic applications, but the mechanisms by which it affects cellular function are unclear. We tested the hypothesis that moderate hypothermia produces broad changes in gene expression by human cells at the level of mRNA. Methods:...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4425 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of human regulatory T cells and effector T cells cultured at standard 37C temperature and in mild hypothermia (33C).
Regulatory T cells (Tregs) play crucial role in maintenance of peripheral tolerance. Numerous clinical trials confirmed safety and efficacy of Treg treatment of for deleterious immune responses. However, Tregs lose their characteristic phenotype and suppressive potential during expansion ex vivo. In...
ORGANISM(S): Homo sapiens 
2017-10-04 | E-MTAB-5322 | biostudies-arrayexpress
TranscriptomicsTissue culture model of hypothermia
Therapeutic hypothermia is a clinically effective treatment for various hypoxic and ischemic conditions, but the associated molecular mechanisms remain unclear. To gain insight into hypothermia-induced transcriptional response, mouse embryonic fibroblasts were exposed to mild hypothermia (32°C) or ...
ORGANISM(S): Mus musculus 
2014-03-01 | E-GEOD-54229 | biostudies-arrayexpress
TranscriptomicsEffects of hypothermia on gene expression in zebrafish gills
Ectothermic vertebrates are different from mammals that are sensitive to hypothermia and they have to maintain core temperature for survival. Why and how ectothermic animals can survive, grow and reproduce in low temperature have been for a long time a scientifically challenging and important inquir...
ORGANISM(S): Danio rerio 
2010-06-20 | E-GEOD-7853 | biostudies-arrayexpress
TranscriptomicsThe Transcriptome Responses of Cardiomyocyte Exposed to Hypothermia
Hypothermia affects the body in positive and negative consequences. In cardiac, hypothermia depresses myocardial contraction, slows conduction, and decreases metabolic rate. However, little is known about the molecular mechanism. Here we compare the genes expression of human adult ventricular cardio...
ORGANISM(S): Homo sapiens 
2015-07-28 | E-GEOD-71361 | biostudies-arrayexpress
UnknownExternal validation of 5A score model for predicting in-hospital mortality among the accidental hypothermia patients: JAAM-Hypothermia study 2018-2019 secondary analysis.
Not available
S-EPMC9134674 | biostudies-literature
ProteomicsFerritin-mediated iron detoxification mediates hypothermia survival in Caenorhabditis elegans and murine neurons.
How animals rewire cellular programs to survive cold is a fascinating problem with potential biomedical implications, ranging from emergency medicine to space travel. Studying a hibernation-like response in the free-living nematode Caenorhabditis elegans, we uncovered a regulatory axis that enhances...
ORGANISM(S): Caenorhabditis elegans 
2022-10-14 | PXD034794 | Pride
Ferritin heavy chain Ferrous iron Foxo Ets-4 Neuroprotection Ferroxidase Daf-16 Fth1 Cold Ftn-1 Pqm-1 Ros Antioxidant Hibernation Iron Fe2+ Hypothermia 
TranscriptomicsTissue culture model of hypothermia
Therapeutic hypothermia is a clinically effective treatment for various hypoxic and ischemic conditions, but the associated molecular mechanisms remain unclear. To gain insight into hypothermia-induced transcriptional response, mouse embryonic fibroblasts were exposed to mild hypothermia (32°C) or n...
ORGANISM(S): Mus musculus 
2014-03-01 | GSE54229 | GEO
GenomicsTherapeutic Hypothermia After Pediatric Cardiac Arrest (In-Hospital) (THAPCA-IH-BioLINCC)
Therapeutic Hypothermia After Pediatric Cardiac Arrest (In-Hospital) (THAPCA-IH-BioLINCC)
PRJNA1453575 | ENA
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