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ProteomicsFerritin-mediated iron detoxification mediates hypothermia survival in Caenorhabditis elegans and murine neurons.
How animals rewire cellular programs to survive cold is a fascinating problem with potential biomedical implications, ranging from emergency medicine to space travel. Studying a hibernation-like response in the free-living nematode Caenorhabditis elegans, we uncovered a regulatory axis that enhances...
ORGANISM(S): Caenorhabditis elegans 
2022-10-14 | PXD034794 | Pride
Ferritin heavy chain Ferrous iron Foxo Ets-4 Neuroprotection Ferroxidase Daf-16 Fth1 Cold Ftn-1 Pqm-1 Ros Antioxidant Hibernation Iron Fe2+ Hypothermia 
TranscriptomicsRNA-seq of LGR5(+) and LGR5(-) cells isolated from human colon adenoma organoids and targeted DNA-seq of a colorectal biobank
This study has two components: (1) Human colon adenoma organoids (n=4 patients) were dissociated into single cells. Cells were incubated with a magnetic bead bound to an LGR5 antibody and run through a magnetic column. Magnet bound cells and flow through negative (FTN) cells were obtained. Magnet bo...
ORGANISM(S): Homo sapiens 
2020-04-30 | E-MTAB-4698 | biostudies-arrayexpress
UnknownHIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage.
Not available
S-EPMC3240588 | biostudies-literature
UnknownMARS1 mutations linked to familial trigeminal neuralgia via the integrated stress response.
Not available
S-EPMC9840295 | biostudies-literature
UnknownInsulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans.
Not available
S-EPMC3291539 | biostudies-literature
UnknownGenome-wide microarrray analysis reveals roles for the REF-1 family member HLH-29 in ferritin synthesis and peroxide stress response.
Not available
S-EPMC3606163 | biostudies-literature
TranscriptomicsExpression data from C. elegans wild type, hlh-25 mutant and hlh-29 mutant strains
In Caenorhabditis elegans, the six proteins that make up the REF-1 family are HES homologs that act in both Notch dependent and Notch-independent pathways to regulate embryonic events. To further our understanding of how the REF-1 family works to coordinate post-embryonic cellular events, we perfor...
ORGANISM(S): Caenorhabditis elegans 
2016-07-03 | E-GEOD-65417 | biostudies-arrayexpress
UnknownFerritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons.
Not available
S-EPMC9391379 | biostudies-literature
UnknownFerritin is regulated by a neuro-intestinal axis in the nematode Caenorhabditis elegans.
Not available
S-EPMC6920132 | biostudies-literature
UnknownL-threonine promotes healthspan by expediting ferritin-dependent ferroptosis inhibition in C. elegans.
Not available
S-EPMC9628521 | biostudies-literature
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