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ProteomicsCharacterization of RAS/RAF/ERK signal cascade as a novel regulating factor in alpha-amanitin-induced liver injury
The well-known hepatotoxicity mechanism resulting from alpha-amanitin (-AMA) exposure arises from RNA polymerase II (RNAP II) inhibition. RNAP Ⅱ inhibition occurs through the dysregulation of mRNA synthesis. However, the signaling pathways in hepatocytes that arise from -AMA have not yet been fully ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035758 | Pride
Alpha-amanitin  toxic mushroom  acute liver failure  global phosphoproteome  ras/raf/erk signaling pathway 
ProteomicsCharacterization of RAS/RAF/ERK signal cascade as a novel regulating factor in alpha-amanitin-induced liver injury
The well-known hepatotoxicity mechanism resulting from alpha-amanitin (-AMA) exposure arises from RNA polymerase II (RNAP II) inhibition. RNAP Ⅱ inhibition occurs through the dysregulation of mRNA synthesis. However, the signaling pathways in hepatocytes that arise from -AMA have not yet been fully ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035817 | Pride
Alpha-amanitin  toxic mushroom  acute liver failure  global phosphoproteome  ras/raf/erk signaling pathway 
ModelsLee2025 EGFR-RAS-RAF-ERK, -sorafenib model
This model describes the biochemical reactions involved in the EGFR-RAS-ERK signaling pathway in context of low RAF1 abundance. Signaling dynamics in the presence of RAF kinase inhibitor, sorafenib, is described by the additional SBML file attached.
2026-02-18 | MODEL2501150001 | BioModels
GenomicsCircRAPGEF5 acts as a modulator of RAS/RAF/MEK/ERK signaling during colorectal carcinogenesis
CircRAPGEF5 acts as a modulator of RAS/RAF/MEK/ERK signaling during colorectal carcinogenesis
PRJNA1121955 | ENA
UnknownInhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit.
Not available
S-EPMC5135640 | biostudies-literature
ProteomicsCharacterization, Antioxidant Effects of Lycium ruthenicum Murr. Polysaccharides and its Protective Effects Against Oxaliplatin-Induced Peripheral Neurotoxicity by Inhibiting the RAS-RAF-MEK-ERK Signaling Pathway
Oxaliplatin is a frequently used chemotherapeutic agent; however, oxaliplatin-induced peripheral neuropathy (OIPN) is a prevalent adverse effect for which no effective treatment currently exists. Lycium ruthenicum Murr. (LR), a traditional Chinese medicinal herb also consumed as food, is rich in pol...
ORGANISM(S): Rattus Norvegicus 
2025-11-26 | PXD071288 |
UnknownTargeting RAS-RAF-MEK-ERK signaling pathway in human cancer: Current status in clinical trials.
Not available
S-EPMC10066287 | biostudies-literature
TranscriptomicsCircRAPGEF5 acts as a modulator of RAS/RAF/MEK/ERK signaling during colorectal carcinogenesis
Mutations in oncogenes such as KRAS, NRAS and BRAF promote cancer cell survival and proliferation, while excessive RAS/RAF/MEK/ERK signaling instead exerts an inhibitory effect on tumor growth. The precise regulatory mechanism of moderate RAS/RAF/MEK/ERK pathway activation during tumorigenesis remai...
ORGANISM(S): Homo sapiens 
2026-06-13 | GSE269456 | GEO
UnknownKinase suppressor of Ras 1 (KSR1) promotes liver carcinogenesis via activation of the RAS/RAF/MEK/ERK signaling pathway.
Not available
S-EPMC12509110 | biostudies-literature
Genomicsena-DATASET-DKFZ-IBIOS-28-05-2015-11:13:32:451-82 - samples
Mutations that activate the RAF-MEK-ERK signaling pathway, in particular BRAFV600E, occur in many cancers, and mutant BRAF-selective inhibitors have clinical activity in these diseases. Activating BRAF alleles are usually considered to be mutually exclusive with mutant RAS, whereas inactivating muta...
EGAD00001001384 | EGA
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