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TranscriptomicsTranscription profiling of Xenopus laevis early gastrulation embryos injected with alpha-amanitin against RNA polymerase II activity
Xenopus laevis embryos were injected with alpha-amanitin to inhibit RNA polymerase II activity. Embryos were allowed to develop up to stage 10.5 (early gastrula, control and alpha-amanitin injected embryos) and subsequently collected for RNA isolation. The transcriptome profiles of alpha-amanitin in...
ORGANISM(S): Xenopus laevis 
2016-03-07 | E-MTAB-3614 | biostudies-arrayexpress
TranscriptomicsRNA expression analysis after RNA polymerase II transcriptional blocking with α-amanitin
Transcriptional profiling of HeLa cells treated with α-amanitin for 9 h. Relative abundance to untreated control cells was used to evaluate the biogenesis of lncRNAs by RNA polymerase II. Two-condition experiment, alpha-amanitin-treated vs. untretated HeLa cells. Biological replicates: 4 with dye-sw...
ORGANISM(S): Homo sapiens 
2015-06-30 | E-GEOD-62989 | biostudies-arrayexpress
ProteomicsCharacterization of protein dynamics after alpha-amanitin exposure in hepatoma cells
Alpha-amanitin (α-AMA) is a cyclic peptide and is one of the most lethal mushroom amatoxins found in Amanita phalloides. α-AMA is known to cause hepatotoxicity through RNA polymerase II inhibition, which acts in RNA and DNA translocation. To investigate the toxic signature of α-AMA beyond known mech...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018702 | Pride
Tric Alpha-amanitin Hepatotoxicity Comparative quantitative proteomics 
TranscriptomicsExpression data for MCF-7 treated with PolII inhibitors, Triptolide or alpha-amanitin
Transcription of mRNA in mammalian is mainly performed by RNA polymerase II (PolII). POLRMT is responsible for the production of cytoplasmic and nuclear form of mitochondrial RNA polymerase. The former (mtRNAP) participates in transcription of RNA in the mitochondria while the latter (spRNAP-IV) is ...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-28444 | biostudies-arrayexpress
ProteomicsCharacterization of hepatocytes secretomes after alpha-amanitin exposure by quantitative proteomics
In the human body, proteins secreted into peripheral blood vessels are known as the secretome, and they serve as a representation of the physiological or pathological status of cells. The unique response of cells to toxin exposure can be confirmed via secretome analysis, which can be applied to disc...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD036476 | Pride
Alpha-amanitin  toxic mushroom  secretomes  exposure marker  complement component 3 
GenomicsGenome-wide CRISPR loss-of-function screen for α-amanitin
Genome-wide CRISPR loss-of-function screen for α-amanitin
PRJNA940199 | ENA
ProteomicsCharacterization of complement C3 as a marker of alpha-amanitin toxicity by comparative secretome profiling
In the human body, proteins secreted into peripheral blood vessels are known as the secretome, and they represent the physiological or pathological status of cells. The unique response of cells to toxin exposure can be confirmed via secretome analysis, which can be used to discover toxic mechanisms ...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD038016 | Pride
Alpha-amanitin  toxic mushroom  secretomes  exposure marker  complement component 3 
ProteomicsCharacterization of RAS/RAF/ERK signal cascade as a novel regulating factor in alpha-amanitin-induced liver injury
The well-known hepatotoxicity mechanism resulting from alpha-amanitin (-AMA) exposure arises from RNA polymerase II (RNAP II) inhibition. RNAP Ⅱ inhibition occurs through the dysregulation of mRNA synthesis. However, the signaling pathways in hepatocytes that arise from -AMA have not yet been fully ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035817 | Pride
Alpha-amanitin  toxic mushroom  acute liver failure  global phosphoproteome  ras/raf/erk signaling pathway 
ProteomicsCharacterization of RAS/RAF/ERK signal cascade as a novel regulating factor in alpha-amanitin-induced liver injury
The well-known hepatotoxicity mechanism resulting from alpha-amanitin (-AMA) exposure arises from RNA polymerase II (RNAP II) inhibition. RNAP Ⅱ inhibition occurs through the dysregulation of mRNA synthesis. However, the signaling pathways in hepatocytes that arise from -AMA have not yet been fully ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035758 | Pride
Alpha-amanitin  toxic mushroom  acute liver failure  global phosphoproteome  ras/raf/erk signaling pathway 
TranscriptomicsRegulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress
Gene expression profile in CS1AN deficient and CSBwt restored cell lines after 24 hours of UV or alphe-amanitin treatment (only for restored). The comaprison of expression profile between 0 and 24 hours revealed continouse suppresion of transcription upon UV treatment in CS1AN cell line and alpha-am...
ORGANISM(S): Homo sapiens 
2014-05-23 | E-GEOD-57923 | biostudies-arrayexpress
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