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MetabolomicsHistone H3K4me3 Demethylase RBP2 Transcriptionally Activates PPARγ to Drive Lipid Metabolic Reprogramming in Gastric Carcinoma

This work investigates epigenetic driven lipid metabolic reprogramming in gastric carcinoma. We characterize that histone H3K4me3 demethylase RBP2 transcriptionally activates PPARgama by binding to its promoter region,thereby promoting lipogenic gene expression and intracellular lipid accumulatio...

2026-08-14 | MTBLS15324 | MetaboLights
GenomicsRNA sequencing of RBP4 or control treated cells
RNA sequencing of RBP4 or control treated cells
PRJNA809736 | ENA
GenomicsAnalysis of miRNA expression profiles of porcine granulosa cells overexpressing RBP4
Analysis of miRNA expression profiles of porcine granulosa cells overexpressing RBP4
PRJNA556246 | ENA
TranscriptomicsAnalysis of miRNA expression profiles of porcine granulosa cells overexpressing RBP4
To illustrate molecular pathways associated with the effects of RBP4 on GCs, we used high-throughput sequencing to detect differential gene expression in GCs overexpressing RBP4.
ORGANISM(S): Sus scrofa 
2019-07-24 | GSE134735 | GEO
TranscriptomicsRNA sequencing of RBP4 or control treated cells
Purpose: The purpose of this study was to find the differentially expressed genes in RBP4 and control treated cells by transcriptome analysis (RNA-seq) for subsequent mechanism study. Methods: Illumina Novaseq™ 6000 was used to sequencing RBP4 and control-treated human umbilical vein endothelial cel...
ORGANISM(S): Homo sapiens 
2025-02-22 | GSE197314 | GEO
TranscriptomicsNext Generation Sequencing analysis of the global expression profiling in bone marrow-derived macrophages (BMDMs) from wild-type and RBP4-deficient mice.
To investigate the influence of retinol-binding protein 4 (RBP4) deficiency on the expression of genes related to cholesterol metabolism, we examined the expression profiling of global genes in BMDMs from wild-type(WT) and RBP4-deficient mice (RBP4-KO) by RNA-seq. The results revealed that expressio...
ORGANISM(S): Mus musculus 
2025-10-10 | GSE290075 | GEO
TranscriptomicsRBP4 inhibits tongue squamous cell carcinoma progression through inhibition of the PI3K/AKT signaling pathway and promotion of macrophage M1-type polarization
Tongue squamous cell carcinoma (TSCC) is a common type of oral mucosal epithelial malignancy that can severely affect patient quality of life. Therefore, novel therapeutic strategies for TSCC are needed. This study aimed to investigate the role and mechanism of action of retinol-binding protein 4 (R...
ORGANISM(S): Homo sapiens 
2026-01-11 | GSE301618 | GEO
GenomicsNext Generation Sequencing analysis of the global expression profiling in bone marrow-derived macrophages (BMDMs) from wild-type and RBP4-deficient mice.
Next Generation Sequencing analysis of the global expression profiling in bone marrow-derived macrophages (BMDMs) from wild-type and RBP4-deficient mice.
PRJNA1226151 | ENA
UnknownHepatocytes Are the Principal Source of Circulating RBP4 in Mice.
Not available
S-EPMC5204311 | biostudies-literature
UnknownThe Hepatokine RBP4 Links Metabolic Diseases to Articular Inflammation.
Not available
S-EPMC10812991 | biostudies-literature
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