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MetabolomicsAzithromycin promotes relapse by disrupting immune and metabolic networks after allogeneic stem cell transplantation
Administration of azithromycin after allogeneic hematopoietic stem cell transplantation for hematological malignancies has been associated with relapse in a randomized phase 3 controlled clinical trial. Studying 240 samples from patients randomized in this trial is a unique opportunity to better und...
2022-08-22 | MTBLS406 | MetaboLights
MetabolomicsSerum metabolomic profiles identify ER-positive early breast cancer patients at increased risk of disease recurrence in a multicentre population

PURPOSE: Detecting signals of micrometastatic disease in early breast cancer (EBC) patients could improve risk stratification and allow better tailoring of adjuvant therapies. We have previously shown that postoperative serum metabolomic profiles are predictive of relapse in a si...

2017-03-02 | MTBLS424 | MetaboLights
MetabolomicsScreening of Differential Metabolites and Metabolic Pathway Analysis Related to Colorectal Adenoma Recurrence

Background To analyze the differences in gut metabolites between the CRA (colorectal adenoma) recurrence and non-recurrence groups, to identify characteristic metabolites and related metabolic pathways associated with recurrence, and to provide new evidence for risk stratification and interv...

2026-08-08 | MTBLS15298 | MetaboLights
MetabolomicsMitochondrial Transplantation of Brown Adipocytes Interferes with the Metabolism of Tumor Stem Cells and Inhibits the Recurrence of Brain Glioma after Operation

Glioblastoma multiforme (GBM) is highly aggressive, with treatment resistance and recurrence driven by metabolically plastic glioma stem cells (GSCs). Inspired by brown adipose tissue (BAT) thermogenesis, researchers transplanted BAT-derived mitochondria (BA-Mito) into GSCs, reducing stemness mar...

2025-08-27 | MTBLS12901 | MetaboLights
ProteomicsProteomics-based approach reveals the involvement of SERPINB9 in recurrent and relapsed multiple myeloma
Multiple myeloma (MM) is a common hematological malignancy with poorly understood recurrence and relapse mechanisms. Notably, bortezomib resistance leading to relapse makes MM treatment significantly challenging. To clarify the drug resistance mechanism, we employed a quantitative proteomics approac...
ORGANISM(S): Homo sapiens (Human) 
2021-03-03 | PXD022182 | Pride
Multiple myeloma  recurrence and relapse  proteomics  parallel reaction monitoring  serpinb9 
TranscriptomicsMicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer
Despite surgical treatment of stage I non-small cell lung cancer (NSCLC), one third of patients will eventually have a recurrence. Robust prognostic markers are required to better manage therapy options. MicroRNAs play important roles in human cancers. The purpose of this study is to identify miRNA ...
ORGANISM(S): Homo sapiens 
2012-03-26 | E-GEOD-29135 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human stage I non-small cell lung cancer to quantify microRNA changes associated with disease recurrence
Expression of 752 microRNAs in 77 cases of stage I non-small cell lung cancer was examined using a locked nucleic acid microarray to quantify microRNA changes associated with recurrence of the disease after surgical resection.
ORGANISM(S): Homo sapiens 
2010-04-07 | E-TABM-727 | biostudies-arrayexpress
TranscriptomicsExpression data from ALL diagnosis and relapse pediatric acute lymphoblastic leukemia cases
There is a distinct signature of differentially expressed probes from diagnosis to relapse Gene expression profiles of pediatric patients with B-precursor ALL were compared to at 2 time points, diagnosis and relapse. The overall design was a comparison of gene expression at diagnosis and relapse wit...
ORGANISM(S): Homo sapiens 
2011-09-23 | E-GEOD-28460 | biostudies-arrayexpress
TranscriptomicsA five-microRNA-signature predicting recurrence in HNSCC
The risk of locoregional or distant failure in advanced HPV-negative head and neck squamous cell carcinoma (HNSCC) patients is high. However, no suitable markers for stratification are clinically available. Thus, we aimed to identify a microRNA(miRNA)-signature predicting disease recurrence. For thi...
ORGANISM(S): Homo sapiens 
2018-09-06 | E-MTAB-5793 | biostudies-arrayexpress
TranscriptomicsDiagnosis-relapse in ALL
Almost a quarter of pediatric patients with Acute Lymphoblastic Leukemia (ALL) suffer from relapses. The biological mechanisms underlying therapy response and development of relapses have remained unclear. In an attempt to better understand this phenomenon, we have analyzed 41 matched diagnosis rel...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-18497 | biostudies-arrayexpress
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