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MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
MetabolomicsMulti-omics analyses reveal regulatory networks underpinning metabolite biosynthesis in Nicotiana tabacum

Tobacco is a significant industrial crop, serving as a model for plant science and a promising specie for the production of proteins and small molecules. However, system biology studies of tobacco under natural field cultivation conditions remain scarce. Here, we construct a genome-scale metaboli...

2025-09-28 | MTBLS13060 | MetaboLights
MetabolomicsA Generalized Strategy to Kill Leukemic Cells by Targeting the Regulatory Systems Governing Mitochondrial Membrane Potential
Targeting mitochondria emerges as a promising anti-leukemia strategy, yet selective mitochondrial disruption remains challenging. Here, we identified elevated mitochondrial membrane potential (MMP) as a hallmark of leukemic transformation and chemotherapy-resistant cells, prompting screening for MMP...
2025-07-11 | MTBLS12596 | MetaboLights
TranscriptomicsMicroarray-based global mapping of integration sites of retrotransposon, intracisternal A-particle, in mouse genome
Mammalian genomes have evolutionary harbored numerous mobile elements, a part of which are still active and evoke genomic instability. Their movement and positional diversity occasionally result in phenotypic changes and variation by causing altered expression and disruption of neighboring genes in...
ORGANISM(S): Mus musculus 
2008-05-03 | E-GEOD-9572 | biostudies-arrayexpress
TranscriptomicsOvalbumin sensitized and challenged induces differential gene expression in mouse lungs
To gain insight into the promoting effect of ultrafine particle inhalation on development and progression of allergic asthma, we selected an experimental approach involving exposure to ultrafine carbon particles (UCP) and gene expression profiling of lungs from mice with experimental, ovalbumin indu...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-6496 | biostudies-arrayexpress
TranscriptomicsUCP exposure of ovalbumin sensitized and challenged mice
To gain insight into the promoting effect of ultrafine particle inhalation on development and progression of allergic asthma, we selected an experimental approach involving exposure to ultrafine carbon particles (UCP) and gene expression profiling of lungs from mice with experimental, ovalbumin indu...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-6571 | biostudies-arrayexpress
ProteomicsCharacterization of the regulatory AAA-ATPase subunit Rpt3 in Plasmodium berghei as an activator of Protein Phosphatase 1
The 26S proteasome is the main proteolytic machine involved in protein degradation, contributing to homeostasis or stress response of eukaryotic cells. This macromolecular complex, consisting of a 20S core particle assembled with one or two 19S regulatory particles, is highly regulated by phos-phory...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-03 | PXD044616 | Pride
Proteasome Rpt3 Protein phosphatase 1 19s regulatory particle Lcms Plasmodium 
UnknownThe regulatory particle of the Saccharomyces cerevisiae proteasome.
Not available
S-EPMC108897 | biostudies-literature
TranscriptomicsThe non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAs
Vault particles are conserved organelles that have been implicated in multidrug resistance and intracellular transport. They are formed by three different proteins and the non-coding vault RNAs (vRNAs). Here we show that human vRNAs produce several small RNAs (svRNAs) by mechanisms different from th...
ORGANISM(S): Homo sapiens 
2009-09-07 | E-GEOD-16060 | biostudies-arrayexpress
UnknownComplete subunit architecture of the proteasome regulatory particle.
Not available
S-EPMC3285539 | biostudies-literature
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