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MetabolomicsShort-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

INTRODUCTION: Bariatric surgery is known to be the most effective treatment for weight loss in obese patients and for the rapid remission of obesity-related comorbidities. These short-term improvements result from not only limited digestion or absorption but also dynamic changes ...

2022-03-17 | MTBLS2472 | MetaboLights
TranscriptomicsTranscription profiling of rats subjected to Roux-en-Y gastruc bypass to characterize of weight loss and weight regain mechanisms
Roux-en-Y gastric bypass (RYGB) is the most effective therapy for morbid obesity, but it has a ~20% failure rate. We used our established RYGB model in diet-induced obese (DIO) Sprague-Dawley rats, which reproduces human bi-phasic body weight (BW) loss pattern, to determine mechanisms contributing t...
ORGANISM(S): Rattus norvegicus 
2008-06-16 | E-GEOD-8314 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skeletal muscle from morbidly obese patients before and after gastric bypass surgery to identify genes responsive to weight loss.
Obesity results from a chronic imbalance between energy intake and energy expenditure, with excess calories stored as fat. As such, weight loss has long been considered as a primary goal of treatment for obesity. A surgical treatment of severe obesity such as gastric bypass provides the most dramati...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-5109 | biostudies-arrayexpress
ProteomicsNovel insights on remnant stomach following Roux-en-Y Gastric Bypass surgery based on histological evaluation and quantitative proteomics analysis
Background: Patients undergoing weight-reducing Roux-en-Y gastric bypass (RYGB) have immediate positive effects on metabolic health, including type 2 diabetes (T2D). Refeeding via the secluded stomach, either by a gastrotube or after gastro-gastric fistulation result in T2D relapse and weight regain...
ORGANISM(S): Homo sapiens (Human) 
2025-07-17 | PXD065508 | Pride
Human  proteomic remnant stomach  roux-en-y gastric bypass 
TranscriptomicsmiRNA profiling by array of human paired adipose tissue (subcutaneous and omentum) before and after gastric-bypass and weight loss
Objective: Adipose tissue plays a key role in obesity related metabolic dysfunction. MicroRNA (miRNA) are gene regulatory molecules involved in inter-cellular and inter-organ communication. We hypothesised that miRNA levels in adipose tissue would change after gastric bypass surgery and that this wo...
ORGANISM(S): Homo sapiens 
2019-12-16 | E-MTAB-8594 | biostudies-arrayexpress
GenomicsGoto-Kakizaki rats with Roux-en-Y gastric bypass surgery
Goto-Kakizaki rats with Roux-en-Y gastric bypass surgery
PRJNA523431 | ENA
TranscriptomicsExpression profile of liver samples from subjects at the time of Roux en Y gastric bypass surgery.
To map the genetics of gene expression in metabolically relevant tissues and investigate the diversity of expression SNPs (eSNPs) in multiple tissues from the same individual, we collected four tissues from approximately 1,000 patients undergoing Roux-en-y gastric bypass and clinical traits associat...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-24293 | biostudies-arrayexpress
TranscriptomicsExpression profile of omental adipose samples from subjects at the time of Roux en Y gastric bypass surgery.
To map the genetics of gene expression in metabolically relevant tissues and investigate the diversity of expression SNPs (eSNPs) in multiple tissues from the same individual, we collected four tissues from approximately 1,000 patients undergoing Roux-en-y gastric bypass and clinical traits associat...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-24294 | biostudies-arrayexpress
TranscriptomicsExpression profile of subcutaneous adipose samples from subjects at the time of Roux en Y gastric bypass surgery.
To map the genetics of gene expression in metabolically relevant tissues and investigate the diversity of expression SNPs (eSNPs) in multiple tissues from the same individual, we collected four tissues from approximately 1,000 patients undergoing Roux-en-y gastric bypass and clinical traits associat...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-24297 | biostudies-arrayexpress
GenomicsRoux-en-Y Gastric Bypass Reduces Podocyte Injury in Diabetic Kidney Disease
Roux-en-Y Gastric Bypass Reduces Podocyte Injury in Diabetic Kidney Disease
PRJNA481023 | ENA
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