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MetabolomicsNR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease

Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide riboside (NR) shows promise for Parkinson’s disease (PD) and other neurodegenerative disorders. However, the optimal dose of NR remains unknown, and doses exceeding 2000 mg daily have not been tested in humans. To ev...

2025-04-09 | MTBLS8812 | MetaboLights
MetabolomicsUntargeted food chemical safety assessment: A proof-of-concept on two analytical platforms and contamination scenarios of tea (Green tea study)
This study aims at assessing the capability of comparing and combining different instrumental platforms in an untargeted approach with a view of detecting chemical contaminants in food matrices at low levels. A strategy based on liquid chromatography-high resolution mass spectrometry (LC-HRMS) and c...
2019-02-12 | MTBLS771 | MetaboLights
MetabolomicsUntargeted food chemical safety assessment: A proof-of-concept on two analytical platforms and contamination scenarios of tea (Black tea study)
This study aims at assessing the capability of comparing and combining different instrumental platforms in an untargeted approach with a view of detecting chemical contaminants in food matrices at low levels. A strategy based on liquid chromatography-high resolution mass spectrometry (LC-HRMS) and c...
2019-02-12 | MTBLS772 | MetaboLights
MetabolomicsSafety and efficacy analysis of in vivo lentiviral gene therapy in pre-clinical ARC syndrome models
Safety and efficacy analysis of in vivo lentiviral gene therapy in pre-clinical ARC syndrome models
2026-04-29 | MTBLS14408 | MetaboLights
GenomicsPrePhage safety
PrePhage safety
PRJNA1126634 | ENA
TranscriptomicsAre Non-animal Systemic Safety Assessments Protective: A Toolbox and Workflow
High throughput transcriptomics using the TempO-Seq (TM) platform for dose response modelling of 3 different cell lines treated with multiple compounds as part of a study to generate a toolbox and workflow for non-animal safety assessments. The data generated here was produced as one part of a toolb...
ORGANISM(S): Homo sapiens 
2025-09-15 | E-MTAB-15258 | biostudies-arrayexpress
ProteomicsToxicological safety evaluation of diallyl trisulfide through acute and subacute toxicity studies in ICR mice
Diallyl trisulfide (DATS) is one of the main sulfide-containing compounds in garlic oil and has been shown to have a variety of biological activities such as anti-tumor, inhibition of inflammation, and immune regulation. However, there is very little information available regarding its toxicological...
ORGANISM(S): Mus Musculus 
2024-03-28 | PXD051045 |
TranscriptomicsTranscription profiling of brain tissue from mice after safety or fear conditioning
safety versus fear conditioning. Mice were trained with 4 unpaired (Safety) or paired (Fear) CS-US presentations over 3 days. Mice were killed by decapitation 4hrs after the last training session.
ORGANISM(S): Mus musculus 
2008-11-28 | E-MEXP-1358 | biostudies-arrayexpress
TranscriptomicsSafety assessment of novel foods using omics profiling combined with one-class classifiers
Food safety evaluation of new, genetically modified (GM) plant varieties has led to basic questions regarding the safety assessment of new plant varieties and whole foods derived thereof. An important part of the hazard identification in the European approach is a targeted compositional analysis of ...
ORGANISM(S): Solanum tuberosum 
2014-03-04 | E-MTAB-1707 | biostudies-arrayexpress
TranscriptomicsExpression profiling in Macaca fascicularis liver samples
The long-tailed macaque, also referred to as cynomolgus monkey (Macaca fascicularis), is one of the most important non-human primate animal models in basic and applied biomedical research. To improve the predictive power of primate experiments for humans, we determined the genome sequence of a Macac...
ORGANISM(S): Macaca fascicularis 
2011-08-24 | E-GEOD-30184 | biostudies-arrayexpress
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