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MetabolomicsThe Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have documented a plasma membrane invagination with a d...

2023-04-19 | MTBLS7006 | MetaboLights
ProteomicsmTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase
Supporting MS data for paper (DOI:10.1016/j.celrep.2024.115179) by Pham, B. et al., titled "mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase". Related to Table S1 - HEK293 - degradomics (HA-2-165 | Unimod:35; 2016; 4 | 126 - Neg Ctrl (WT cells...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-29 | MSV000095724 | MassIVE
ProteomicsSalvage pathway maintains functional respiratory complex I
Regulation of the turnover of complex I (CI), the largest mitochondrial respiratory chain complex remains enigmatic, despite huge advancement in understanding its structure and the assembly steps in recent years. Although some studies indicated that CI might be remodelled in response to various stim...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-05 | PXD014897 | Pride
Mitochondrial respiratory complex i  proteolytic control  salvage pathway  respiratory deficiency  clpxp protease 
ProteomicsNovel genetic mutations in pyrimidine salvage pathway enzymes from Cryptococcus neoformans contribute to reduced susceptibility against 5-fluorocytosine
The most common cause of cryptococcal meningitis is Cryptococcus neoformans. The addition of 5-fluorocytosine to the treatment of patient with this potentially fatal infection significantly improves disease outcome. However, developing resistance to this drug is a serious problem in patient manageme...
ORGANISM(S): Cryptococcus neoformans var. grubii Cryptococcus neoformans var. neoformans 
2024-07-29 | PXD044249 | Pride
Pyrimidine salvage pathway Proteomics Cryptococcus neoformans Resistance 5-fluorocytosine 
ProteomicsNAD Salvage Supports Serine Biosynthesis
Maintenance of NAD+ levels by mitochondrial complex I, the NAD+ salvage pathway, and other routes is an important factor in of neurodegenerative disease and cancer. Both the production of NAD+ and the metabolic enzymes that require it as a redox cofactor or substrate differ widely in abundance acros...
ORGANISM(S): Homo sapiens (Human) 
2018-08-14 | PXD007790 | Pride
Serine Complex i Fk866 Nad 
GenomicsThe Mgs1/WRNIP1 ATPase is required to prevent a recombination salvage pathway at damaged replication forks
The Mgs1/WRNIP1 ATPase is required to prevent a recombination salvage pathway at damaged replication forks
PRJNA594414 | ENA
UnknownThe NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis.
Not available
S-EPMC6402325 | biostudies-literature
GenomicsThe Mgs1/WRNIP1 ATPase is required to prevent a recombination salvage pathway at damaged replication forks
DNA damage tolerance (DDT) is crucial for genome integrity maintenance. DDT is mainly carried out by template switch recombination, an error-free mode of overcoming DNA lesions, or translesion DNA synthesis, which is error-prone. Here we investigated the role of Mgs1/WRNIP1 in modulating DDT. Using ...
ORGANISM(S): Saccharomyces cerevisiae 
2020-04-20 | GSE141712 | GEO
ProteomicsA novel purine salvage pathway protects CD8 T cells from metabolic stress
Chronic metabolic stress impacts the immune cell function, increasing the incidence of autoimmune diseases and cancers. Whether past history of a high fat diet (HFD) leads to immune dysfunction is less understood. Moreover, whether factors other than persistent epigenetic changes would impact on the...
ORGANISM(S): Mus Musculus (mouse) 
2026-02-09 | PXD063309 | JPOST Repository
GenomicsInhibition of the hepatic vitamin B12-dependent methionine-salvage pathway by trichloroethylene metabolites accounts for the formic aciduria in the rat
Inhibition of the hepatic vitamin B12-dependent methionine-salvage pathway by trichloroethylene metabolites accounts for the formic aciduria in the rat
PRJNA505919 | ENA
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