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TranscriptomicsMapping and characterization of promoter-binding sites of protein phosphatase 1
Protein phosphatase 1 (PP1) is a Ser/Thr phosphatase that has been implicated in many key cellular functions including transcriptional regulation. Due to its involvement these many processes, it becomes difficult to directly link PP1 to transcriptional regulation on the chromatin level as no direct ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-54170 | biostudies-arrayexpress
ProteomicsAurora B opposes PP1 function in mitosis through phosphorylation of the conserved RVxF binding motif in PP1 regulatory proteins
Protein phosphatase 1 (PP1) is a highly conserved protein phosphatase that opposes the actions of a diverse set of Ser-Thr protein kinases by controlling the majority of serine-threonine (Ser-Thr) dephosphorylation reactions in eukaryotes. PP1 gains substrate specificity through binding to a large n...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-03-30 | MSV000082226 | MassIVE
ProteomicsLoss of Serine/Threonine Protein Phosphatase 6 Severely Impairs Sexual Stage Development in Malaria Parasite Plasmodium berghei
Protein phosphorylation plays a critical role during the development of malaria parasites. Here, we performed a functional analysis of the Plasmodium berghei Ser/Thr protein phosphatase 6 (PbPP6), which was associated with the plasma membrane of macrogametes and ookinetes. Compared to wild-type P. b...
ORGANISM(S): Plasmodium berghei 
2025-06-27 | PXD063164 | Pride
Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite plasmodium berghei 
ProteomicsLoss of Serine/Threonine Protein Phosphatase 6 Severely Impairs Sexual Stage Development in Malaria Parasite Plasmodium berghei
Protein phosphorylation plays a critical role during the development of malaria parasites. Here, we performed a functional analysis of a Plasmodium berghei Ser/Thr protein phosphatase 6 (PbPP6), which was associated with the plasma membrane of macrogametes and ookinetes. Compared with the wild-type ...
ORGANISM(S): Plasmodium berghei ANKA 
2025-06-27 | PXD053412 | Pride
Plasmodium  ser/thr protein phosphatase 6  gametogenesis  ca2+ signaling cascade  pkg 
TranscriptomicsRNA-seq analysis of S. pneumoniae Pn-STP (PhpP) mutants
We report the mRNA expression profile of Streptococcus pneumoniae Type 2 D39 strain-derived mutant lacking the phpP gene encoding eukaryote-type ser/thr phosphatase . Measuring transcriptome profiling in D39Î?phpP mutants vs D39-WT pneumococcus wild-type strain
ORGANISM(S): Streptococcus pneumoniae 
2016-10-27 | E-GEOD-74421 | biostudies-arrayexpress
ProteomicsLoss of Serine/Threonine Protein Phosphatase 6 Severely Impairs Sexual Stage Development in Malaria Parasite Plasmodium berghei
Protein phosphorylation plays a critical role during the development of malaria parasites. Here, we performed a functional analysis of the Plasmodium berghei Ser/Thr protein phosphatase 6 (PbPP6), which was associated with the plasma membrane of macrogametes and ookinetes. Compared to wild-type P. b...
ORGANISM(S): Plasmodium berghei 
2025-06-03 | PXD063225 | Pride
Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite plasmodium berghei 
TranscriptomicsMicroarray analysis of S. pyogenes Type M1-CdhA55(-) mutant
A total of 192 genes were found to be differentially expressed; 38 genes of them were up regulated and 154 genes were down regulated. Most notably the functional categories that were affected include carbohydrate metabolism and cell envelop realted genes ( 56, 29.1% of the total),Virulence genes (1...
ORGANISM(S): Streptococcus pyogenes 
2010-10-01 | E-GEOD-15598 | biostudies-arrayexpress
TranscriptomicsExpression of AWR5 in wild type and cdc55 deletion mutant at 6 h of induction
Expressing the type III effector AWR5 of the phytopathogen Ralstonia solanacearum in yeast cells causes cessation of growth and transcriptional changes reminiscent of inhibition of the TOR pathway. Deletion of cdc55, a regulatory subunit of the PP2A Ser/Thr protein phosphatase eliminates the strong ...
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-31 | E-GEOD-70331 | biostudies-arrayexpress
ProteomicsMapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA
Protein phosphatase 2A (PP2A) is an essential Ser/Thr phosphatase that regulates a plethora of cellular processes. PP2A operates as a holoenzyme complex, comprising one each of the scaffolding (A), regulatory (B) and catalytic (C) subunits. PPP2CA is the principal catalytic subunit of the PP2A holoe...
ORGANISM(S): Homo sapiens (Human) 
2024-03-18 | PXD045779 | Pride
Targeted protein degradation Ppp2ca Phosphatase Dtag Phospho-proteomics Phosphorylation Pp2a Kinase Protac Substrate landscape 
GenomicsOsmotic stress induces phosphorylation of histone H3 at threonine 3 in pericentromeric regions of Arabidopsis thaliana [ChIP-Seq]
Histone phosphorylation plays key roles in stress-induced transcriptional reprogramming in metazoans but its function(s) in land plants has remained relatively unexplored. Here we report that an Arabidopsis mutant defective in At3g03940 and At5g18190, encoding closely related Ser/Thr protein kinases...
ORGANISM(S): Arabidopsis thaliana 
2015-07-22 | E-GEOD-68370 | biostudies-arrayexpress
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