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Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

Chemical biology strategies for directly perturbing protein homeostasis including the degradation tag (dTAG) system provide temporal advantages over genetic approaches and improved selectivity over small molecule inhibitors. We describe dTAGV-1, an exclusively selective VHL-recruiting dTAG molecule,...

ORGANISM(S): Homo sapiens (Human)

2020-09-21 | PXD018937 | Pride

ATAC-seq data of mouse embryonic stem cells treated with dTAG for SALL4 depletion against untreated control

This study investigates the role of SALL4 in regulating chromatin accessibility. SALL4 was tagged with FKBP to enable dTAG-inducible degradation. ATAC-seq was performed at multiple time-points (1 hour, 4 hours and 8 hours) following dTAG treatment to capture changes in chromatin accessibility upon S...

ORGANISM(S): Mus musculus

2026-01-15 | E-MTAB-15375 | biostudies-arrayexpress

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules.

Not available

S-EPMC7501296 | biostudies-literature

The dTAG system for immediate and target-specific protein degradation.

Not available

S-EPMC6295913 | biostudies-literature

Use of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities.

Not available

S-EPMC10306401 | biostudies-literature

RNA-seq analysis after dTAG-mediated MYB depletion in Jurkat cells