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MetabolomicsCE-MS Metabolomic and LC-MS Proteomic Analyses of Breast Cancer Exosomes Reveal Alterations in Purine and Carnitine Metabolism

A nano sheath-flow capillary electrophoresis mass spectrometry (CE-MS) system with electrospray ionization was used to profile cationic metabolite cargo in exosomes secreted by non-tumorigenic MCF-10A and tumorigenic MDA-MB-231 breast epithelial cells. CE-MS-based metabolomics revealed increased ...

2024-11-14 | MTBLS11190 | MetaboLights
TranscriptomicsMicroRNA profiling of brain metastasis competent cell-derived exosomes
Objective of this work was to characterize the miRNA profile of exosomes isolated from brain-homing cell lines (MDA-MB-231BR, CTC1BMSM, and 70W) with their respective parental non-brain metastatic cell lines (MDA-MB-231P, CTC1P and MeWo). Exosomes derived from the six cell lines were isolated. Brain...
ORGANISM(S): Homo sapiens 
2013-07-16 | E-GEOD-48934 | biostudies-arrayexpress
ProteomicsProteomic Profiling of Serum Exosomes from Patients with Metastatic Gastric Cancer
Clinical management of metastatic gastric cancer (mGC) remains a major challenge due to a lack of specific biomarkers and effective therapeutic targets. Recently, accumulating evidence has suggested that exosomes play an essential role in cancer metastasis and can be an excellent reservoir of novel ...
ORGANISM(S): Homo sapiens (Human) 
2020-06-29 | PXD019387 | Pride
Metastatic gastric cancer  serum exosomes  lc-ms/ms 
ProteomicsMacaca mulatta serum exosomes MS
Aging is a major risk factor for various forms of disease. An enhanced understanding of the physiological mechanisms related to aging is urgently needed. Nonhuman primates (NHPs) have the closest genetic relationship to humans, making them an ideal model to explore the complicated aging process. Mul...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2024-06-22 | PXD030287 | Pride
Exosomes Ms Serum Macaca mulatta 
TranscriptomicsmicroRNA profiles of exosomes: Exosomes from Pooled Healthy donors' serum vs. Exosomes from Pooled NPC Patients' serum
microRNA profiles of Exosomes from Pooled NPC Patients serum comparing Control Exosomes from Healthy donors serum Two-condition experiment, Exosomes from Pooled Healthy donors serum vs. Exosomes from Pooled NPC Patients serum. Biological replicates: 1 Exosomes from Pooled Healthy donors serum, 1 E...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-57319 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiles of immune cells and their exosomes
Microarray analysis of exosomal miRNAs vs the miRNAs of their respective donor cells. To determine the miRNA repertoires of exosomes secreted by immune cells, we isolated exosomes from cell supernatants of the Raji B cell line, the Jurkat-derived J77 T cell line, and primary dendritic cells (DCs) de...
ORGANISM(S): Homo sapiens 
2011-03-17 | E-GEOD-27997 | biostudies-arrayexpress
Proteomicscomparative proteome analysis of serum exosomes from newborn piglets inresponse to porcine epidemic diarrhea virus infection
The immune system is thought to be fragile in the neonate, which is susceptible to pathogens. Exosomes are a type of vehicles existing in the body fluid and participate in many biological processes, especially the immune response. Inorder to investigate the roles that exosomes may play during virus ...
ORGANISM(S): ssRNA viruses Sus scrofa domesticus (domestic pig) 
2019-04-30 | PXD010762 | Pride
Neonate Complement Serum exosome Porcine epidemic diarrhea virus Antiviral effect 
TranscriptomicsRNA-seq of non coding RNA from serum exosomes of GC patients and healthy individuals
The dysregulation of exosomal microRNAs (miRNAs) play a crucial role in the development and progression of cancer. Differentially expressed miRNAs were identified in serum exosomes of GC patients and healthy individuals using next-generation sequencing and bioinformatics.
ORGANISM(S): Homo sapiens 
2023-11-01 | E-MTAB-12763 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis of serum-purified exosomes reveals putative pre-eclampsia associated biomarkers
The high incidence of pre-eclampsia, affecting 5-10% of pregnancies, makes it a major health problem. Early detection of pre-eclampsia, before the appearance of the first clinical symptoms, is therefore an urgent need, since it would allow the early intervention. Identification of plasma/serum bioma...
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD025308 | Pride
Pre-eclampsia Exosome Proteomics Pregnancy Mass spectrometry Plasma Serum Biomarkers Cohort studies 
TranscriptomicsmRNA profiles of activated and resting T cells and their exosomes
Microarray analysis of exosomal and cellular mRNAs in activated and resting primary human T lymphoblasts Primary human T lymphoblasts were obtained from eight donors and total RNA was isolated from cells and derived exosomes before and after activation with PMA plus ionomycin.
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-50971 | biostudies-arrayexpress
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