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TranscriptomicsTranscription profiling of placenta from women who underwent a normal pregnancy and from those suffering from early or late onset pre-eclampsia
Pre-eclampsia is one of the most serious pregnancy-associated disorders, and is defined by hypertension (systolic blood pressure higher than 140mmHg or diastolic blood pressure higher than 90mmHg) with proteinuria (more than 0.3g/day). It is not a simple complication of pregnancy, but is rather a sy...
ORGANISM(S): Homo sapiens 
2008-05-07 | E-GEOD-4707 | biostudies-arrayexpress
GenomicsWTCCC2 Pre-eclampsia
Genotype data from the Affymetrix 6.0 platform for 4,375 Colombian pre-eclampsia cases and controls
EGAD00010001647 | EGA
GenomicsWTCCC2 Pre-eclampsia Study
A WTCCC2 project genome-wide association study for pre-eclampsia (PA) in 4375 individuals from Colombia, genotyped on the Affymetrix 6.0 array.
EGAS00001003349 | EGA
ProteomicsQuantitative proteomic analysis of serum-purified exosomes reveals putative pre-eclampsia associated biomarkers
The high incidence of pre-eclampsia, affecting 5-10% of pregnancies, makes it a major health problem. Early detection of pre-eclampsia, before the appearance of the first clinical symptoms, is therefore an urgent need, since it would allow the early intervention. Identification of plasma/serum bioma...
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD025308 | Pride
Pre-eclampsia Exosome Proteomics Pregnancy Mass spectrometry Plasma Serum Biomarkers Cohort studies 
TranscriptomicsDifferential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia
To determine differential expression of microRNAs in placentae with severe pre-eclampsia and normal placenta. Differential expression of microRNAs in placentae (4 severe pre-eclampsia and 4 normal control) was screened by microarray platform, then some differential microRNAs were selected and valida...
ORGANISM(S): Homo sapiens 
2011-04-14 | E-GEOD-15789 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of deciduas from pre-eclamptic and normotensive pregnancies
Genome-wide analysis of decidual transcriptome in pre-eclampsia compared with normotensive controls to find differentially expressed genes/pathways. Preeclampsia (PE) is a common and serious pregnancy hypertensive disorder with a strong genetic component. The study aims were to use genome-wide analy...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-60438 | biostudies-arrayexpress
TranscriptomicsGene expression profiling for placentas from pre-eclamptic, unexplained FGR and normal pregnancies.
It has been well documented that pre-eclampsia and unexplained fetal growth restriction (FGR) has a common etiological background, but little is known about the linkage al the molecular level. we have performed global gene expression profiling by oligonucleotide microarrays for placentas from pre-ec...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-24129 | biostudies-arrayexpress
GenomicsPre-eclampsia TAC-seq
Pre-eclampsia TAC-seq
PRJNA516433 | ENA
ProteomicsEffect of aberrant PlGF on endometrial stromal cell actin dynamics : implications in pre-eclampsia.
High levels of placental growth factor (PlGF) are pathological, however its function in endometrial cells remains to be investigated. Cell proliferation and motility requires actin reorganization, which is under the control of various signalling pathways including Rac1 and PAK1 proteins. In this stu...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050237 | Pride
Actin polymerization Cell stiffness Endometrial cells Angiogenesis Pre-eclampsia. 
TranscriptomicsRNAseq of human endometrial monocytes and macrophages in healthy controls and pre-eclampsia
The aim of this experiment was to identify differential gene expression pathways in human endometrial FACS-enriched monocytes (CD45+CD66b-Siglec8-CD3-CD19-CD20-HLA-DR+CD64+CD14+CCR2+ cells), Mac1 macrophages (CD45+CD66b-Siglec8-CD3-CD19-CD20-HLA-DR+CD64+CD14+CCR2- CD206- cells), Mac2 macrophages (CD...
ORGANISM(S): Homo sapiens 
2026-07-16 | E-MTAB-15397 | biostudies-arrayexpress
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