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ProteomicsAP-MS analysis of sirtuin-4 interactions in human fibroblasts
Sirtuins (SIRTs) form a critical family of nicotinamide adenine dinucleotide (NAD)-dependent enzymes that govern genome regulation, metabolism, and aging. Despite conserved deacetylase domains, SIRTs4-7 have little to no deacetylase activity, and a robust catalytic activity for mitochondrial SIRT4 h...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-04 | MSV000079557 | MassIVE
GenomicsSirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling
Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling
PRJNA980290 | ENA
UnknownVisualization of Sirtuin 4 Distribution between Mitochondria and the Nucleus, Based on Bimolecular Fluorescence Self-Complementation.
Not available
S-EPMC6953047 | biostudies-literature
UnknownMitochondrial sirtuin 4 shapes the intestinal microbiota of Drosophila by controlling lysozyme expression.
Not available
S-EPMC12166577 | biostudies-literature
UnknownWolbachia and Sirtuin-4 interaction is associated with alterations in host glucose metabolism and bacterial titer.
Not available
S-EPMC7584242 | biostudies-literature
ProteomicsAP-MS analysis of sirtuin-4 interactions in human fibroblasts
Sirtuins (SIRTs) form a critical family of nicotinamide adenine dinucleotide (NAD)-dependent enzymes that govern genome regulation, metabolism, and aging. Despite conserved deacetylase domains, SIRTs4-7 have little to no deacetylase activity, and a robust catalytic activity for mitochondrial SIRT4 h...
ORGANISM(S): Homo sapiens (Human) 
2015-01-05 | PXD001447 | Pride
Protein interactions Sirt4 Pdh Sirtuin 
UnknownDecreased sirtuin 4 levels promote cellular proliferation and invasion in papillary thyroid carcinoma.
Not available
S-EPMC11466257 | biostudies-literature
TranscriptomicsSirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling
Sirtuin 4 (SIRT4) is a mitochondrially-localized stress-responsive NAD+-dependent deacylase predominantly regulating energy metabolism and ROS homeostasis. While SIRT4 has been implicated in pathological cardiac hypertrophy, underlying mechanisms remain incompletely understood. Here, we show that my...
ORGANISM(S): Mus musculus 
2025-06-05 | GSE234210 | GEO
UnknownSirtuin 4 (Sirt4) downregulation contributes to chondrocyte senescence and osteoarthritis via mediating mitochondrial dysfunction.
Not available
S-EPMC10878156 | biostudies-literature
UnknownMitochondrial Sirtuin 4 Resolves Immune Tolerance in Monocytes by Rebalancing Glycolysis and Glucose Oxidation Homeostasis.
Not available
S-EPMC5854658 | biostudies-literature
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