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ProteomicsMutant EGFR is a preferred SMURF2 substrate of ubiquitination: role in enhanced receptor stability and TKI sensitivity
We previously reported that differential protein degradation of TKI-sensitive [L858R, del(E746-A750)] and resistant (T790M) epidermal growth factor receptor (EGFR) mutants upon erlotinib treatment correlates with drug sensitivity. However, the molecular mechanism remains unclear. We also reported SM...
ORGANISM(S): Homo sapiens (Human) 
2020-07-29 | PXD018324 | Pride
Epidermal growth factor receptor (egfr)  smad ubiquitination regulatory factor 2 (smurf2)  ubiquitin conjugating enzyme h5 (ubch5)  protective ubiquitination  tyrosine kinase inhibitor (tki) resistance  lc-ms 
ProteomicsPhosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response
Timely repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preventing illnesses induced by genetic abnormalities. We previously demonstrated that the E3 ubiquitin ligase Smad ubiquitin regulatory factor 2 (SMURF2) plays a critical tumor suppressing role via i...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-10-26 | PXD021420 | Pride
Smurf2 Atm Phosphorylation Dna damage response 
UnknownA novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone.
Not available
S-EPMC7680794 | biostudies-literature
UnknownTumor-suppressive role of Smad ubiquitination regulatory factor 2 in patients with colorectal cancer.
Not available
S-EPMC8971512 | biostudies-literature
UnknownSmad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness.
Not available
S-EPMC2639752 | biostudies-literature
UnknownCoupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.
Not available
S-EPMC2972958 | biostudies-literature
UnknownThe protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2).
Not available
S-EPMC2978571 | biostudies-literature
UnknownThe ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation.
Not available
S-EPMC6779433 | biostudies-literature
UnknownUbiquitin ligase SMURF2 enhances epidermal growth factor receptor stability and tyrosine-kinase inhibitor resistance.
Not available
S-EPMC7476725 | biostudies-literature
UnknownmiR-1225-3p regulates fibrosis in mesangial cells via SMURF2-mediated ubiquitination of ChREBP in diabetic kidney disease.
Not available
S-EPMC11995769 | biostudies-literature
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