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ProteomicsPhosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response
Timely repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preventing illnesses induced by genetic abnormalities. We previously demonstrated that the E3 ubiquitin ligase Smad ubiquitin regulatory factor 2 (SMURF2) plays a critical tumor suppressing role via i...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-10-26 | PXD021420 | Pride
Smurf2 Atm Phosphorylation Dna damage response 
ProteomicsRegulatory role of E3 ubiquitin ligase Smurf2 on transcriptional corepressor KAP1
An E3 ubiquitin ligase Smurf2 and transcriptional co-repressor KAP1 have been documented to play crucial roles in similar cellular pathways including cell cycle, DNA damage response, chromatin compaction, senescence and cell death. Smurf2 and KAP1, through regulation of these cellular processes eith...
ORGANISM(S): Homo sapiens (Human) 
2022-04-07 | PXD029642 | Pride
Human Kap1 E3 ubiquitin ligase Ubiquitination Smurf2 
ProteomicsMutant EGFR is a preferred SMURF2 substrate of ubiquitination: role in enhanced receptor stability and TKI sensitivity
We previously reported that differential protein degradation of TKI-sensitive [L858R, del(E746-A750)] and resistant (T790M) epidermal growth factor receptor (EGFR) mutants upon erlotinib treatment correlates with drug sensitivity. However, the molecular mechanism remains unclear. We also reported SM...
ORGANISM(S): Homo sapiens (Human) 
2020-07-29 | PXD018324 | Pride
Epidermal growth factor receptor (egfr)  smad ubiquitination regulatory factor 2 (smurf2)  ubiquitin conjugating enzyme h5 (ubch5)  protective ubiquitination  tyrosine kinase inhibitor (tki) resistance  lc-ms 
GenomicsEffect of Smurf1 or Smurf2 deficiency on Gene Expression Profiling of aged mouse liver tissues
Effect of Smurf1 or Smurf2 deficiency on Gene Expression Profiling of aged mouse liver tissues
PRJNA454813 | ENA
UnknownSkeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes.
Not available
S-EPMC4729489 | biostudies-literature
ProteomicsADAR1 interactome analysis, LC-MS/MS
Adenosine-to-inosine (A-to-I) RNA editing catalyzed by ADAR1 plays essential roles in the regulation of diverse molecular and cellular processes both under physiological conditions and in the disease states, including cancer. However, mechanisms governing the protein abundance and activity of ADAR1,...
ORGANISM(S): Homo sapiens (Human) 
2022-05-29 | PXD025338 | Pride
Human embryonic kidney hek-293t cells lc-ms/ms 
Proteomicsc-Met activation leads to the establishment of a TGFβ receptor regulatory network required for bladder cancer invasion
Treatment of muscle-invasive bladder cancer remains a major clinical challenge. Aberrant HGF/c-MET upregulation and activation is frequently observed in bladder cancer correlating with cancer progression and invasion. However, the precise mechanisms underlying HGF/c-MET mediated invasion in bladder ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-26 | PXD014736 | Pride
C-met Emt Bladder cancer invasion Phosphorylation Tgfb Smurf2 
UnknownDevelopment and characterisation of SMURF2-targeting modifiers.
Not available
S-EPMC7808752 | biostudies-literature
UnknownSmurf2 up-regulation activates telomere-dependent senescence.
Not available
S-EPMC535914 | biostudies-literature
TranscriptomicsEffect of Smurf1 or Smurf2 deficiency on Gene Expression Profiling of aged mouse liver tissues
Transcriptome analysis of RNAs extracted from livers of wild type or Smurf1 knock out (KO) or Smurf2 KO mice at age of 11 month old. We prepared RNA from the following groups: livers of Wild type (WT) or Smurf1 KO or Smurf2 KO mouse from mixed Black Swiss/129SvEv background at age of 11 month old. T...
ORGANISM(S): Mus musculus 
2018-12-19 | GSE113995 | GEO
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