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ProteomicsThe tumor suppressor SOCS1 diminishes tolerance to oxidative stress in hepatocellular carcinoma
SOCS1 is a tumor suppressor in hepatocellular carcinoma. Recently we showed that loss of SOCS1 in hepatocytes promotes NRF2 activation. Here we investigated how SOCS1 expression affected oxidative stress response in HCC cells. Murine Hepa1-6 cells expressing SOCS1 (Hepa-SOCS1) or control vector (Hep...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-22 | PXD047908 | Pride
Hepatocellular carcinoma  socs1  oxidative stress  cisplatin  tert-butyl hydroperoxide  mass spectrometry 
TranscriptomicsIGR_PBI_SOCS1_GE_JP
Suppressor of cytokine signaling (SOCS1) is an inducible negative regulator of cytokine signaling. SOCS1 is expressed in normal colonic epithelium and colon adenocarcinomas. However, the levels of SOCS1 decreased during progression of colon adenocarcinomas, the lowest level being found in the more ...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-MTAB-1742 | biostudies-arrayexpress
ProteomicsARAP2 regulates the Interferon-gamma response by restricting SOCS1
Interferon-gamma (IFNγ) is a critical cytokine required to coordinate anti-viral immunity in response to pathogens such as influenza. IFNγ signals through the JAK-STAT pathway, inducing a tyrosine-phosphorylation cascade that ensures a potent immune response. Aberrant JAK-STAT signaling can drive hy...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD060300 | Pride
Influenza Socs1 Interferon Ifn gamma Jak Stat 
ProteomicsSILAC-based quantitative proteomics implicates SOCS1 in modulating protein constituents of large macromolecular complexes in hepatocytes
Suppressor of Cytokine Signaling 1 (SOCS1) functions as a tumor suppressor in hepatocellular carcinoma by regulating cytokine, growth factor and other signaling pathways. The tumor suppressor functions of SOCS1 are mediated partly via promoting ubiquitination and proteasomal degradation of several s...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-01 | PXD019135 | Pride
Cbl Socs1 Met Silac Ubiquitination Proteasome 
GenomicsSOCS1
SOCS1
PRJNA647451 | ENA
TranscriptomicsSuppressor of cytokine signaling-1 influences bacterial clearance and pathology during the infection with Mycobacterium tuberculosis
Tuberculosis results from an interaction between a chronically persistent pathogen counteracted by IFN-g-mediated immune responses. Modulation of IFN-g signaling could therefore constitute a major immune evasion mechanism for M. tuberculosis. SOCS1 plays a major role in the inhibition of IFN-g-media...
ORGANISM(S): Mus musculus 
2012-01-18 | E-GEOD-23508 | biostudies-arrayexpress
GenomicsInterferons promote autophagy via the STAT1/STAT5B-SOCS1 axis
Interferons promote autophagy via the STAT1/STAT5B-SOCS1 axis
PRJNA1290249 | ENA
TranscriptomicsContext- and cell-type specific function of miR155-Socs1 interaction in immune regulation
The microRNA (miRNA) dependent regulation of gene expression confers robustness to cellular phenotypes and controls responses to extracellular stimuli. Although a single miRNA can regulate expression of hundreds of target genes, it is unclear whether any of its distinct biological functions can be d...
ORGANISM(S): Mus musculus 
2015-05-10 | E-GEOD-68511 | biostudies-arrayexpress
GenomicsEffect of SOCS1 overexpression on AML gene expression in OCI-AML2 cell line
Effect of SOCS1 overexpression on AML gene expression in OCI-AML2 cell line
PRJNA1218726 | ENA
UnknownTumour-promoting role of SOCS1 in colorectal cancer cells.
Not available
S-EPMC4585755 | biostudies-literature
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