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Proteomicsi.e., Human HEK-293F cell line AP-MS/MS analysis of oxidative modifications in SPATA5.
The objective of this project was to identify oxidative modifications of the SPATA5 protein in C672 cells through proteomic analysis. This involved the affinity purification of SPATA5 under overexpression conditions, followed by detailed proteomic analysis to characterize the oxidative modifications...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054917 | Pride
Hek-293f Ap-msms I. e. human 
ProteomicsMuscular and molecular pathology associated with SPATA5-deficiency in a child with EHLMRS
Mutations in the SPATA5-gene are associated with the Epilepsy, Hearing Loss and Mental Retardation Syndrome (EHLMRS). While SPATA5 is ubiquitously expressed and is attributed a role in mitochondrial morphogenesis during spermatogenesis, there is only limited knowledge on the associated muscular and ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026182 | Pride
Ehlmrs  spata5  mitochondrial disorder  muscle proteomics  myopathology 
ProteomicsChemical crosslinking of the SPATA5-SPATA5L1-C1orf109-CINP complex
Here we present data using chemical crosslinking to inform on the architecture of the SPATA5-SPATA5L1-C1orf109-CINP complex (or the 55LCC).
ORGANISM(S): Homo sapiens (Human) 
2024-04-17 | PXD035980 | Pride
55lcc Xl-ms Unfoldase 
UnknownCompound heterozygous SPATA5 variants in four families and functional studies of SPATA5 deficiency.
Not available
S-EPMC5838984 | biostudies-literature
UnknownMutations in SPATA5 Are Associated with Microcephaly, Intellectual Disability, Seizures, and Hearing Loss.
Not available
S-EPMC4564988 | biostudies-literature
UnknownMuscular and Molecular Pathology Associated with SPATA5 Deficiency in a Child with EHLMRS.
Not available
S-EPMC8345956 | biostudies-literature
UnknownSPATA5 mutations cause a distinct autosomal recessive phenotype of intellectual disability, hypotonia and hearing loss.
Not available
S-EPMC5041579 | biostudies-literature
UnknownCryo-EM structure of the AAA+ SPATA5 complex and its role in human cytoplasmic pre-60S maturation.
Not available
S-EPMC12019325 | biostudies-literature
UnknownLabeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a late step in human ribosome assembly.
Not available
S-EPMC9004343 | biostudies-literature
UnknownThe SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity.
Not available
S-EPMC11055677 | biostudies-literature
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