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TranscriptomicsTranscriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation.
Splicing factor SRSF10 is known to function as a sequence-specific splicing activator. Here, we used RNA-seq coupled with bioinformatics analysis to identify the extensive splicing network regulated by SRSF10 in chicken cells. We found that SRSF10 promoted both exon inclusion and exclusion. Function...
ORGANISM(S): Gallus gallus 
2014-01-22 | E-GEOD-53354 | biostudies-arrayexpress
TranscriptomicsSRSF10 regulates alternative splicing and is required for adipocyte differentiation.
During adipocyte differentiation, significant alternative splicing changes occur in association with the adipogenic process. However, little is known about roles played by splicing factors in this process. We observed that mice deficient for the splicing factor SRSF10 exhibit severely impaired devel...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-54226 | biostudies-arrayexpress
TranscriptomicsRegulation of Vertebrate Nervous System-Specific Alternative Splicing and Development by an SR-Related Protein
Alternative splicing is a key process underlying the evolution of increased proteomic and functional complexity and is especially prevalent in the mammalian nervous system. However, the factors and mechanisms governing nervous system-specific alternative splicing are not well understood. Through a g...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-16187 | biostudies-arrayexpress
TranscriptomicsThe splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression
Gene expression and splicing switches upon RBM4 overexpression 2 Samples
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-58594 | biostudies-arrayexpress
TranscriptomicsAn EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.
Regulation of cell-cell junction formation and regulation of cell migration were enriched among EMT (Epithelial-Mesenchymal Transition)-associated alternatively splicing events. Our analysis suggested that most EMT-associated alternative splicing events are regulated by one or more members of the RB...
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-30290 | biostudies-arrayexpress
TranscriptomicsRBFOX1 Splicing and Transcriptional Regulation in Neurons
We used RNA sequencing to identify the RBFOX1 splicing network at a genome-wide level in primary human neural stem cells during differentiation. We observe that RBFOX1 regulates a large set of alternative splicing events implicated in neurogenesis and cell maintenance. Subsequent alterations in gene...
ORGANISM(S): Homo sapiens 
2012-06-28 | E-GEOD-36710 | biostudies-arrayexpress
TranscriptomicsAn PWI- and RRM Motif-Containing Protein Is Critical for Pre-mRNA Splicing and ABA Responses in Arabidopsis
We used RNA-seq platform to determine role of a splicing factor RBM25 in regulation of gene expression and pre-mRNA splicing. We found that a loss-of-function allele of RBM25, rbm25-1, causes up- and down-regulation of a large number of genes. We further found that the rbm25-1 mutation results in d...
ORGANISM(S): Arabidopsis thaliana 
2015-10-28 | E-GEOD-66737 | biostudies-arrayexpress
TranscriptomicsThe epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate alternative splicing events
Epithelial Splicing Regulatory Proteins 1 and 2 (ESRP1 and ESRP2) are recently discovered epithelial-specific RNA-binding proteins that promote splicing of the epithelial variant of the FGFR2, ENAH, CD44, and CTNND1 transcripts. To catalogue a larger set of splicing events under the regulation of t...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-17468 | biostudies-arrayexpress
TranscriptomicsLIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance
This SuperSeries is composed of the following subset Series: GSE39855: LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (splicing array) GSE39872: LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (HTS) Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-09-10 | E-GEOD-39873 | biostudies-arrayexpress
TranscriptomicsGlobal regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR) [RNA-seq]
Alternative mRNA splicing is a major mechanism for gene regulation and transcriptome diversity. Despite the extent of the phenomenon, the regulation and specificity of the splicing machinery are only partially understood. Adenosine-to-inosine (A-to-I) RNA editing of pre-mRNA by ADAR enzymes has been...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-47997 | biostudies-arrayexpress
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