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ProteomicsPAXIP1 and STAG2 converge to maintain 3D genome archi-tecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription
How steroid hormone receptors (SHRs) orchestrate transcriptional activity remains only partly understood. Upon activation, SHRs bind the genome and recruit their co-regulators, crucial to induce gene expression. However, it remains unknown which components of the SHR-recruited coregulator complex ar...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD038902 | Pride
Lc-msms  paxip1  stag2  rime glucocorticoid receptor 
TranscriptomicsRecurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy [GPL6984]
STAG2 is a novel UBC tumor suppressor acting through mechanisms that are different from its role to prevent aneuploidy Gene copy number analyses of STAG2 in urinary bladder tumors. R values were extracted from beadstudio and normalised using the pounds method. Log R Ratios were calculated using an a...
ORGANISM(S): Homo sapiens 
2013-10-24 | E-GEOD-51589 | biostudies-arrayexpress
TranscriptomicsRecurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy [GPL6983]
STAG2 is a novel UBC tumor suppressor acting through mechanisms that are different from its role to prevent aneuploidy Gene copy number analyses of STAG2 in urinary bladder tumors. R values were extracted from beadstudio and normalised using the pounds method. Log R Ratios were calculated using an a...
ORGANISM(S): Homo sapiens 
2013-10-24 | E-GEOD-51640 | biostudies-arrayexpress
GenomicsATAC-sequencing in control and Stag2 knockdown cells
We performed ATAC-sequencing in LSK cells (Lin(neg)/c-Kit(+)/Sca-1(+)) from shRNA mice carrying an shRNA for either Renilla or Stag2. ATAC-sequencing control (Renilla) and Stag2 knockdown cells.
ORGANISM(S): Mus musculus 
2015-09-16 | E-GEOD-72367 | biostudies-arrayexpress
TranscriptomicsTruncating mutations of STAG2 define a molecular subgroup of aneuploid bladder cancers with poor prognosis.
Aneuploidy is among the most common hallmarks of cancer, yet the underlying genetic mechanisms are still poorly defined. We have recently identified STAG2 as a gene that is mutated in human cancer and whose inactivation leads directly to chromosomal instability and aneuploidy. However, no single tum...
ORGANISM(S): Homo sapiens 
2013-06-30 | E-GEOD-41581 | biostudies-arrayexpress
ProteomicsIdentification of the protein interaction network of STAG2 protein isoforms with inclusion and exclusion of exon32
This study involves the identification of specific interactors for STAG2ex32+ and STAG2ex32delta. Plasmids expressing YFP-STAG2 isoforms were transfected into HCT116OsTIR cells using untransfected cells as mock control. 40h post transfection, whole cell lysates were extracted and STAG2 isoforms were...
ORGANISM(S): Homo sapiens (Human) 
2023-05-04 | PXD041975 | Pride
Ap-ms 
GenomicsExpression profiling in STAG2 mutant K562 cells
Expression profiling in STAG2 mutant K562 cells
PRJNA543745 | ENA
GenomicsChromatin accessibility profiling in STAG2 mutant K562 cells
Chromatin accessibility profiling in STAG2 mutant K562 cells
PRJNA543744 | ENA
GenomicsThe effect of STAG2 loss in Ewing sarcoma
The effect of STAG2 loss in Ewing sarcoma
PRJNA450012 | ENA
GenomicsA STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis
A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis
PRJNA1161652 | ENA
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