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MetabolomicsStreamlined identification of strain engineering targets for bioprocess improvement using metabolic pathway enrichment analysis
Metabolomics is a powerful tool for the identification of genetic targets for bioprocess optimisation. However, in most cases, only the biosynthetic pathway directed to product formation is analysed, limiting the identification of these targets. Some studies have used untargeted metabolomics, allowi...
2023-08-31 | MTBLS6667 | MetaboLights
MetabolomicsCreation and Characterization of a Genomically Hybrid Strain in the Nitrogen-Fixing Symbiotic Bacterium Sinorhizobium meliloti
Many bacteria, often associated with eukaryotic hosts and of relevance for biotechnological applications, harbor a multipartite genome composed of more than one replicon. Biotechnologically relevant phenotypes are often encoded by genes residing on the secondary replicons. A synthetic biology approa...
2021-03-17 | MTBLS576 | MetaboLights
TranscriptomicsComparative Genomics Reveals New Molecular targets for Accelerated Improvement of Erythromycin-producing Strains
Information about molecular mechanisms underlying improvement of antibiotic-producing microorganisms with traditional mutation and screening approach is largely missing. This information is essential to develop rational approaches to strain improvement. In this study by using comparative genomic ana...
ORGANISM(S): Saccharopolyspora erythraea 
2012-05-23 | E-GEOD-30600 | biostudies-arrayexpress
TranscriptomicsComparative genomics reveals new molecular targets for accelerated strain improvement of rifamycin B-producing strains
In the present study, we have used a genomic approach to understand how the classical mutate-and-screen method actually generated an improved rifamycin B producer. Compared with the reference strains Amycolatopsis mediterranei S699 (rifamycin B producer) and U32 (rifamycin SV producer), a total of 2...
ORGANISM(S): Amycolatopsis mediterranei S699 
2014-08-26 | E-GEOD-51015 | biostudies-arrayexpress
TranscriptomicsMolecular analysis of a microbial strain improvement paradigm
Industrial production of penicillins with the filamentous fungus Penicillium chrysogenum is based on an unprecedented effort in microbial strain improvement. Sequencing of the 32.19 Mb genome of P. chrysogenum Wisconsin54-1255 revealed many genes responsible for key steps in penicillin production. D...
ORGANISM(S): Penicillium chrysogenum 
2008-12-01 | GSE9825 | GEO
TranscriptomicsGenome changes associated with a Zymomonas mobilis sodium acetate-tolerant mutant (AcR)
We report the genome changes associated with a Zymomonas mobilis sodium acetate-tolerant mutant (AcR). We used comparative genomics, transcriptomics, and genetics to show nhaA over-expression conferred sodium acetate (NaAc) tolerance in Z. mobilis. We observed a synergistic effect for sodium and ace...
ORGANISM(S): Zymomonas mobilis 
2010-05-05 | E-GEOD-18106 | biostudies-arrayexpress
TranscriptomicsSinorhizobium meliloti cells: untreated 1021 wild type strain vs. RD64 strain
Nitrogen (N) and phosphorus (P) are the most limiting factors for plant growth. Some microorganisms improve the uptake and availability of N and P minimizing chemical fertilizers dependence. It has been published that the RD64 strain, a Sinorhizobium meliloti 1021 strain engineered to overproduce...
ORGANISM(S): Sinorhizobium meliloti 
2010-05-20 | E-GEOD-21744 | biostudies-arrayexpress
TranscriptomicsA Sinorhizobium meliloti IAA-overproducing strain improves phosphate solubilization and Medicago plant yield
This SuperSeries is composed of the following subset Series: GSE21735: Sinorhizobium meliloti cells: untreated 1021 strain vs. 1021 treated with 2,4-dichlorophenoxyacetic acid (2,4-D) GSE21737: Sinorhizobium meliloti cells: untreated 1021 strain vs. 1021 treated with indole-3-acetic acid (IAA) GSE21...
ORGANISM(S): Sinorhizobium meliloti 
2010-05-20 | E-GEOD-21745 | biostudies-arrayexpress
TranscriptomicsSinorhizobium meliloti cells: untreated 1021 strain vs. 1021 treated with indole-3-acetic acid (IAA)
Nitrogen (N) and phosphorus (P) are the most limiting factors for plant growth. Some microorganisms improve the uptake and availability of N and P, minimizing chemical fertilizer dependence. It has been published that the RD64 strain, a Sinorhizobium meliloti 1021 strain engineered to overproduce i...
ORGANISM(S): Sinorhizobium meliloti 
2010-05-20 | E-GEOD-21737 | biostudies-arrayexpress
TranscriptomicsSinorhizobium meliloti cells: untreated 1021 strain vs. 1021 treated with tryptophan (Trp)
Nitrogen (N) and phosphorus (P) are the most limiting factors for plant growth. Some microorganisms improve the uptake and availability of N and P, minimizing chemical fertilizer dependence. It has been published that the RD64 strain, a Sinorhizobium meliloti 1021 strain engineered to overproduce i...
ORGANISM(S): Sinorhizobium meliloti 
2010-05-20 | E-GEOD-21743 | biostudies-arrayexpress
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