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TranscriptomicsmicroRNAs involved in neuropathic pain following a peripheral nerve injury
Peripheral nerve injury alters the expression of hundreds of proteins in dorsal root ganglia (DRG). Targeting some of these proteins has led to successful treatments for acute pain, but not for sustained postoperative neuropathic pain. The latter may require targeting multiple proteins. Since a sin...
ORGANISM(S): Rattus norvegicus 
2014-09-29 | E-GEOD-60033 | biostudies-arrayexpress
ProteomicsRac1 inhibition prevents cytoskeleton dysfunction and axonal degeneration in Transthyretin Amyloid Polyneuropathy
Transthyretin Amyloid Polyneuropathy (ATTR-PN) is characterized by the deposition of amyloidogenic TTR particularly in dorsal root ganglia (DRG) and peripheral nerve axons leading to a sensory axonopathy. Here, we investigated the role of cytoskeleton alterations in peripheral axons from an ATTR-PN ...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-10 | PXD054291 | Pride
Transthyretin  axonopathy  transthyretin amyloid polyneuropathy  cytoskeleton  microtubule dynamics  actin  axonal transport  peripheral nervous system  rac1 
TranscriptomicsSural nerve of progressive and non-progressive diabetic neuropathy patients
Diabetic neuropathy (DN) is a common complication of diabetes. While multiple pathways are implicated in the pathophysiology of DN, there are no specific treatments for DN and currently it is not possible to predict DN onset or progression. To examine gene expression signatures related to DN, micro...
ORGANISM(S): Homo sapiens 
2010-09-24 | E-GEOD-24290 | biostudies-arrayexpress
ProteomicsComplement profiling on sural nerves of patients with chronic inflammatory demyelinating polyneuropathy
Overall, 55 sural nerve biopsies from patients with CIDP (n=36) and CIDP-variants (n=18) were included into the study. Immunohistochemical analysis of the sural nerve specimens showed an aberrant deposition of terminal complement complex C5b-9 on endoneural capillaries in 52 (94%) of patients in add...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD056286 | Pride
Proteomics Gene expression Chronic inflammatory demyelinating polyneuropathy  complement profiles  sural nerve 
TranscriptomicsTranscription profiling of rat Postnatal developmental changes in Sprague-Dawley animals in the model of neuropathic pain - spare nerve injury
Neuropathic pain is an apparently spontaneous experience triggered by abnormal physiology of the peripheral or central nervous system, which evolves with time. Neuropathic pain arising from peripheral nerve injury is characterized by a combination of spontaneous pain, hyperalgesia and allodynia. The...
ORGANISM(S): Rattus norvegicus 
2010-01-30 | E-GEOD-15041 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat adult and neonate dorsal horn after sciatic nerve injury
As rats do not develop neuropathic pain like hypersensitivity as neonates post nerve injury but do as adults we have used these arrays to help define the processes involved in this process. Rat spinal cord (ipsilateral dorsal horn) was assayed 7 days post SNI injury to the sciatic nerve relative to ...
ORGANISM(S): Rattus norvegicus 
2009-11-10 | E-GEOD-18803 | biostudies-arrayexpress
UnknownRisk Factors of Sural Nerve Axonal Degeneration Using Clinically Relevant Thresholds in Context of Glucose Metabolism: The Maastricht Study.
Not available
S-EPMC12803540 | biostudies-literature
UnknownSural Nerve Perfusion in Mice.
Not available
S-EPMC7758475 | biostudies-literature
UnknownThe Medial Antebrachial Cutaneous Nerve Is a Low-Morbidity Alternative to the Standard Sural Nerve Autograft.
Not available
S-EPMC11571714 | biostudies-literature
UnknownSubjective outcome related to donor site morbidity after sural nerve graft harvesting: a survey in 41 patients.
Not available
S-EPMC3848941 | biostudies-literature
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