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MetabolomicsThe telomere-to-telomere (T2T) genome of Peucedanum praeruptorum Dunn provides insights into the genome evolution and coumarin biosynthesis

BACKGROUND: Traditional Chinese medicine has used Peucedanum praeruptorum Dunn (Apiaceae) for a long time. Various coumarins, including the significant root constituents Praeruptorin (A-E), are the active constituents of the dried roots of P. praeruptorum. Previous trans...

2024-04-02 | MTBLS8679 | MetaboLights
MetabolomicsTelomere-to-telomere genome of Stylosanthes guianensis uncovers symbiotic adaptation to phosphorus-deficient soils
Thirty-day-old Stylosanthes guianensis seedlings were subjected to two treatments: inoculation with Bradyrhizobium (Br) strain LZ3-2 and treatment without Br inoculation (Control). Following transplantation into acidic soil, root samples were harvested 60 days after transplanting, flash-frozen in li...
2026-05-21 | MTBLS14548 | MetaboLights
TranscriptomicsTelomere dysfunction and fusion during the progression of chronic lymphocytic leukaemia: evidence for a telomere crisis
We performed single-molecule telomere length and telomere fusion analysis in patients at different stages of chronic lymphocytic leukaemia (CLL). Our work identified the shortest telomeres ever recorded in primary human tissue reinforcing the concept that there is significant cell division in CLL. F...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-22016 | biostudies-arrayexpress
TranscriptomicsTelomere length effect on genes near the telomere in myoblasts
We examined differential expression of genes within 10MBs of telomeres in myoblasts with long or short telomeres We offer telomere looping with telomere length as a partial mechanistic explanation for the changes gene expression that is observed. Compare expression of genes within 10MB of the telome...
ORGANISM(S): Homo sapiens 
2014-07-17 | E-GEOD-48973 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of acute telomere dysfunction in the mouse liver using adenoviral mediated, transient expression of a dominant negative version of TRF
Telomere dysfunction induces two types of cellular responses: cellular senescence and apoptosis. Here we analyzed the influence of the cellular level of telomere dysfunction and the role of p53 on induction of apoptosis and senescence in mouse liver using the experimental system of adenoviral mediat...
ORGANISM(S): Mus musculus 
2006-11-21 | E-MEXP-141 | biostudies-arrayexpress
TranscriptomicsDistinctions between the stasis and telomere attrition senescence barriers in cultured human mammary epithelial cells
Molecular distinctions between the stasis and telomere attrition senescence barriers in cultured human mammary epithelial cells Normal human epithelial cells in culture have generally shown a limited proliferative potential of ~10-40 population doublings before encountering a stress-associated sene...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-16058 | biostudies-arrayexpress
GenomicsThe telomere-binding protein Tbf1 demarcates snoRNA gene promoters in Saccharomyces cerevisiae
The majority of Saccharomyces cerevisiae snoRNA promoters contain an aRCCCTaa sequence motif located at the upstream border of a TATA-containing nucleosome-free region. Genome-wide ChIP-seq analysis showed that these motifs are bound in vivo by Tbf1, a telomere-binding protein known to recognize mam...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-28 | E-GEOD-20870 | biostudies-arrayexpress
TranscriptomicsTelomeric repeats facilitate CENP-A incorporation via telomere binding proteins
The histone H3 variant, CENP-ACnp1, is normally assembled upon canonical centromeric sequences, but there is no apparent obligate coupling of sequence and assembly, suggesting that centromere location can be epigenetically determined. To explore the tolerances and constraints on CENP-ACnp1 depositio...
ORGANISM(S): Schizosaccharomyces pombe 
2013-08-22 | E-GEOD-46427 | biostudies-arrayexpress
TranscriptomicsTelomere behavior in a hybrid yeast
Telomeres and the protein/RNA complexes involved in maintaining them are rapidly evolving systems across eukaryotes. Using two Saccharomyces species, S. cerevisiae and S. bayanus, we provide evidence that the telomere systems of these two closely related yeasts have evolved significantly apart and t...
ORGANISM(S): Saccharomyces bayanus 
2010-05-19 | E-GEOD-15877 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast strains harbouring a temperature sensitive allele of the essential telomere capping gene cdc13-1 to investigate the genome-wide response to uncapped telomeres
Telomeres are nucleoprotein complexes that protect the ends of eukaryotic chromosomes from being recognised as double strand breaks. When telomere structure is perturbed, a co-ordinated series of events to promote arrest of the cell cycle is rapidly initiated so that cells carrying damaged telomeres...
ORGANISM(S): Saccharomyces cerevisiae 
2010-02-24 | E-MEXP-1551 | biostudies-arrayexpress
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