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ProteomicsAssessment of global peptide abundance in TOE1 depleted myeloid leukaemia cells
Acute myeloid leukaemia (AML) is an aggressive haematological malignancy characterised by the clonal proliferation of myeloid progenitor cells in the bone marrow and peripheral blood. Dysregulation of the Wnt/β-catenin pathway has been implicated in the establishment and maintenance of leukaemic ste...
ORGANISM(S): Homo sapiens (Human) 
2026-04-29 | PXD070891 | Pride
Aml  hel  oci-aml2  toe1  hspc  human  shrna  leukaemia 
GenomicsTranscriptomic analysis reveals the potential role of TOE1 in hepatocellular carcinoma
Transcriptomic analysis reveals the potential role of TOE1 in hepatocellular carcinoma
PRJNA1301130 | ENA
ProteomicsA Molecular Clamp Targeting the TOE1:Sm Complex Imparts Tunable Regulation of Splicing
Small nuclear RNAs (snRNAs) are required for the structure and function of the spliceosome. The RNA exonuclease TOE1 trims and matures the 3’ ends of snRNAs, but how this post-transcriptional process contributes to spliceosome activity remains poorly understood. Here we report a potent and selective...
ORGANISM(S): Homo sapiens (Human) 
2025-11-11 | PXD070450 | Pride
Cancer Snrna Human Toe1 
ProteomicsA Molecular Clamp Targeting the TOE1:Sm Complex Imparts Tunable Regulation of Splicing
Small nuclear RNAs (snRNAs) are required for the structure and function of the spliceosome. The RNA exonuclease TOE1 trims and matures the 3’ ends of snRNAs, but how this post-transcriptional process contributes to spliceosome activity remains poorly understood. Here we report a potent and selective...
ORGANISM(S): Homo sapiens (Human) 
2025-11-11 | PXD070435 | Pride
Cancer Snrna Human Toe1 
ProteomicsA Molecular Clamp Targeting the TOE1:Sm Complex Imparts Tunable Regulation of Splicing
Small nuclear RNAs (snRNAs) are required for the structure and function of the spliceosome. The RNA exonuclease TOE1 trims and matures the 3’ ends of snRNAs, but how this post-transcriptional process contributes to spliceosome activity remains poorly understood. Here we report a potent and selective...
ORGANISM(S): Homo sapiens (Human) 
2025-11-11 | PXD070432 | Pride
Cancer Snrna Human Toe1 
UnknownToe1 promotes proliferation and differentiation of neural progenitor cells.
Not available
S-EPMC11535345 | biostudies-literature
GenomicsPARN and TOE1 constitute a 3′ end maturation module for nuclear non-coding RNAs
PARN and TOE1 constitute a 3′ end maturation module for nuclear non-coding RNAs
PRJNA437251 | ENA
TranscriptomicsTranscriptomic analysis reveals the potential role of TOE1 in hepatocellular carcinoma
This study integrates bioinformatics analysis and in vitro cellular experiments to elucidate the role of TOE1 (Target of EGR1) in Hepatocellular Carcinoma (HCC) progression. TOE1, a deadenylase belonging to the DEDD exonuclease superfamily, is primarily localized in the Cajal bodies of the nucleus. ...
ORGANISM(S): Homo sapiens 
2026-01-12 | GSE304375 | GEO
UnknownTranscriptomic analysis reveals the potential role of TOE1 in hepatocellular carcinoma.
Not available
S-EPMC12764802 | biostudies-literature
UnknownTOE1 is an inhibitor of HIV-1 replication with cell-penetrating capability.
Not available
S-EPMC4491801 | biostudies-literature
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