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ProteomicsBombardier mediates delivery of short-form Bomanins in the Drosophila Toll response
Toll mediates a robust and effective innate immune response across vertebrates and invertebrates. In Drosophila melanogaster, activation of Toll by systemic infection drives the accumulation of a rich repertoire of immune effectors in hemolymph, including the recently characterized Bomanins as well ...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2019-10-25 | MSV000084509 | MassIVE
TranscriptomicsHuman Toll-Like Receptors Pathway Array Data
Endothelial cell (EC) Toll-like receptor 2 (TLR2) activation upregulates the expression of inflammatory mediators and of TLR2 itself, and modulates important endothelial functions, including coagulation and permeability. We defined TLR2 signaling pathways in ECs, and tested the hypothesis that TLR2 ...
ORGANISM(S): Homo sapiens 
2011-11-04 | E-GEOD-33449 | biostudies-arrayexpress
ProteomicsAbsolute Protein Quantitation of the Mouse Macrophage Toll-Like Receptor and Chemotaxis Pathways
The Toll-like receptor and chemotaxis pathways are key components of the innate immune system. Computational modeling and simulation at the molecular interaction level can be used to study complex biological pathways, but protein concentration values must be input as model parameters. In this invest...
ORGANISM(S): Mus Musculus 
2022-08-15 | PXD031697 | panorama
ProteomicsFormation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry
Tissue morphogenesis requires the spatial control over actomyosin contractility to drive cell shape changes. How developmental patterning information controls cell mechanics is poorly understood. In the Drosophila embryo ectoderm, Myosin-II is enriched at the interface between antero-posterior neigh...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-04-22 | PXD017895 | Pride
Lc-msms Cirl Myo-ii Lrr Drosophila Planar polarity Toll-8 Gpcr 
TranscriptomicsBulk RNAseq of Anopheles gambiae hemocytes upon Toll pathway overactivation
Toll pathway is a key mediator of antiplasmodial immunity and its mechanism of action is dependent on hemocytes (mosquito white blood cells). Anopheles gambiae were injected with dsRNA for Cactus, an inhibitor of the Toll pathway. Cactus silencing over activates the Toll pathway. The goal of this ex...
ORGANISM(S): Anopheles gambiae 
2021-12-16 | E-MTAB-11252 | biostudies-arrayexpress
TranscriptomicsDistinct roles for Toll and autophagy pathways in double-stranded RNA toxicity in a Drosophila model of expanded repeat neurodegenerative diseases
Dominantly inherited expanded repeat neurodegenerative diseases are typically caused by the expansion of existing variable copy number tandem repeat sequences in otherwise unrelated genes. Repeats located in translated regions encode polyglutamine that is thought to be the toxic agent, however in se...
ORGANISM(S): Drosophila melanogaster 
2013-04-05 | E-GEOD-42910 | biostudies-arrayexpress
TranscriptomicsMalaria primes the innate immune response due to IFNg induced enhancement of Toll-like receptor expression and function.
Patients with febrile malaria were recruited in order to determine Peripheral Blood Mononuclear Cell (PBMC) gene expression during malaria. Blood was harvested from patients during the acute phase of the illness, and then patients were given a curative regimen of antimalarials. Three to four weeks...
ORGANISM(S): Homo sapiens 
2009-03-13 | E-GEOD-15221 | biostudies-arrayexpress
ProteomicsAedes aegypti Malpighian tubules are immunologically activated following systemic Toll activation
Canine heartworm is a widespread and potentially fatal mosquito-borne disease caused by infections with the parasitic nematode, Dirofilaria immitis. We have previously shown that systemic activation of the Toll immune pathway via silencing of the negative regulator Cactus in Aedes aegypti blocks par...
ORGANISM(S): Aedes aegypti 
2024-08-27 | PXD036225 | Pride
Aedes  hemolymph  lfq  cactus  toll 
TranscriptomicsTranscription profiling of human TLR2/1 stimulated human monocytes with the Mycobacterium tuberculosis derived 19kDa lipopeptide reveals Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-re...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-8921 | biostudies-arrayexpress
TranscriptomicsToll-like receptor 2 (TLR2)-TLR9 crosstalk dictates IL-12 family cytokine production in microglia
Microglia are the resident mononuclear phagocytes of the CNS parenchyma and represent an initial line of defense against invading microorganisms. Microglia utilize Toll-like receptors (TLRs) for pathogen recognition and TLR2 specifically senses conserved motifs of gram-positive bacteria including li...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-24935 | biostudies-arrayexpress
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