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ProteomicsFormation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry
Tissue morphogenesis requires the spatial control over actomyosin contractility to drive cell shape changes. How developmental patterning information controls cell mechanics is poorly understood. In the Drosophila embryo ectoderm, Myosin-II is enriched at the interface between antero-posterior neigh...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-04-22 | PXD017895 | Pride
Lc-msms Cirl Myo-ii Lrr Drosophila Planar polarity Toll-8 Gpcr 
TranscriptomicsSuppression of molecular inflammatory pathways by Toll-like Receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation
Psoriasis is a complex inflammatory disease resulting from the activation of T helper (Th) 1 and Th17 cells. Recent evidence suggests that abnormal activation of Toll-like receptors (TLRs) 7, 8 and 9 contributes to the initiation and maintenance of psoriasis. We have evaluated the effects of TLR a...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-50400 | biostudies-arrayexpress
ProteomicsBombardier mediates delivery of short-form Bomanins in the Drosophila Toll response
Toll mediates a robust and effective innate immune response across vertebrates and invertebrates. In Drosophila melanogaster, activation of Toll by systemic infection drives the accumulation of a rich repertoire of immune effectors in hemolymph, including the recently characterized Bomanins as well ...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2019-10-25 | MSV000084509 | MassIVE
TranscriptomicsmiRNA array for LPS-activated tnc+/+ and tnc-/- macrophages
Endogenous molecules generated upon pathogen invasion or tissue damage serve as danger signals that activate host defence, however their precise immunological role remains unclear. Tenascin-C is an extracellular matrix glycoprotein that is specifically induced upon injury and infection. We have show...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-41584 | biostudies-arrayexpress
UnknownFormation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry.
Not available
S-EPMC8207821 | biostudies-literature
UnknownOptimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity.
Not available
S-EPMC7050994 | biostudies-literature
TranscriptomicsSustained Efficacy and Seroconversion with the Toll-Like Receptor 7 Agonist GS-9620 in the Woodchuck Model of Chronic Hepatitis B
Background & Aims: New therapies for chronic hepatitis B (CHB) are urgently needed since current treatments rarely lead to cure. We evaluated whether the oral small molecule toll-like receptor (TLR7) agonist GS-9620 could induce durable anti-viral efficacy in woodchucks chronically infected with woo...
ORGANISM(S): Marmota monax 
2015-04-16 | E-GEOD-67935 | biostudies-arrayexpress
TranscriptomicsAnalysis of temporal mRNA expression changes in cultured keratinocytes from Casp-8F/M-bM-^@M-^SK5-Cre and Casp-8F/+K5-Cre mice
Expression of enzymatically inactive caspase-8, or deletion of caspase-8 from basal epidermal keratinocytes, triggers chronic skin inflammation in mice. Unlike similar inflammation resulting from arrest of NF-kB activation in the epidermal cells, the effect induced by caspase-8 deficiency did not de...
ORGANISM(S): Mus musculus 
2009-07-29 | E-GEOD-17345 | biostudies-arrayexpress
UnknownToll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium.
Not available
S-EPMC3192845 | biostudies-literature
UnknownToll-like receptor 8: augmentation of innate immunity in platinum resistant ovarian carcinoma.
Not available
S-EPMC3666910 | biostudies-literature
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