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MetabolomicsA lipidomic human population and translational feeding study of hepatic steatosis and de novo lipogenesis (Human plasma assay)
Background: Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Our aims were to investigate whether a sub-set of TAGs were as...
2018-03-13 | MTBLS616 | MetaboLights
MetabolomicsA lipidomic human population and translational feeding study of hepatic steatosis and de novo lipogenesis (Murine liver assay)
Background: Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Our aims were to investigate whether a sub-set of TAGs were as...
2018-03-12 | MTBLS614 | MetaboLights
ProteomicsPathology tissue-quantitative mass spectrometry analysis to profile histone post-translational modification patterns in patient samples
Histone post-translational modifications (hPTMs) generate a complex combinatorial code that has been implicated with various pathologies, including cancer. Dissecting such a code in physiological and diseased states may be exploited for epigenetic biomarker discovery, but hPTM analysis in clinical s...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2016-08-25 | MSV000080100 | MassIVE
TranscriptomicsThe anti-Shine-Dalgarno sequence drives translational pausing and codon choice in bacteria
Protein synthesis by ribosomes takes place on a linear substrate but at variable speeds. Transient pausing of ribosomes can impact a variety of co-translational processes, including protein targeting and folding. These pauses are influenced by the sequence of the mRNA. Thus redundancy in the genetic...
ORGANISM(S): Escherichia coli 
2012-04-01 | E-GEOD-35641 | biostudies-arrayexpress
ProteomicsPAT-H-MS coupled with laser microdissection to study histone post-translational modifications in selected cell populations from pathology samples
Aberrations in histone post-translational modifications (hPTMs) have been linked with various pathologies, including cancer, and could represent not only useful biomarkers, but also suggest possible targetable epigenetic mechanisms. We have recently developed an approach, termed pathology tissue ana...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-07-17 | PXD006027 | Pride
Laser microdissection Epigenetic marker Histone post-translational modifications Proteomics Mass spectrometry Pat-h-ms Formalin-fixed paraffin embedded 
UnknownPathology Tissue-quantitative Mass Spectrometry Analysis to Profile Histone Post-translational Modification Patterns in Patient Samples.
Not available
S-EPMC4813706 | biostudies-literature
UnknownPAT-H-MS coupled with laser microdissection to study histone post-translational modifications in selected cell populations from pathology samples.
Not available
S-EPMC5504751 | biostudies-literature
UnknownRules of engagement: Promoting academic-industry partnership in the era of digital pathology and artificial intelligence.
Not available
S-EPMC9163695 | biostudies-literature
GenomicsCaloric restriction combined with immobilization as translational model for sarcopenia expressing key-pathways of human pathology
Caloric restriction combined with immobilization as translational model for sarcopenia expressing key-pathways of human pathology
PRJNA879339 | ENA
ProteomicsPathology tissue-quantitative mass spectrometry analysis to profile histone post-translational modification patterns in patient samples
Histone post-translational modifications (hPTMs) generate a complex combinatorial code that has been implicated with various pathologies, including cancer. Dissecting such a code in physiological and diseased states may be exploited for epigenetic biomarker discovery, but hPTM analysis in clinical s...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2015-10-14 | PXD002669 | Pride
Biomarker  epigenetics  ffpe  super-silac  cancer 
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