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ProteomicsPAT-H-MS coupled with laser microdissection to study histone post-translational modifications in selected cell populations from pathology samples
Aberrations in histone post-translational modifications (hPTMs) have been linked with various pathologies, including cancer, and could represent not only useful biomarkers, but also suggest possible targetable epigenetic mechanisms. We have recently developed an approach, termed pathology tissue ana...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-07-17 | PXD006027 | Pride
Laser microdissection Epigenetic marker Histone post-translational modifications Proteomics Mass spectrometry Pat-h-ms Formalin-fixed paraffin embedded 
UnknownPAT-H-MS coupled with laser microdissection to study histone post-translational modifications in selected cell populations from pathology samples.
Not available
S-EPMC5504751 | biostudies-literature
UnknownMass-spectrometry analysis of histone post-translational modifications in pathology tissue using the PAT-H-MS approach.
Not available
S-EPMC4927966 | biostudies-literature
ProteomicsPathology tissue-quantitative mass spectrometry analysis to profile histone post-translational modification patterns in patient samples
Histone post-translational modifications (hPTMs) generate a complex combinatorial code that has been implicated with various pathologies, including cancer. Dissecting such a code in physiological and diseased states may be exploited for epigenetic biomarker discovery, but hPTM analysis in clinical s...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2016-08-25 | MSV000080100 | MassIVE
UnknownPossible Reaction Mechanisms Involved in Degradation of Patulin by Heat-Assisted Cysteine under Highly Acidic Conditions.
Not available
S-EPMC9610101 | biostudies-literature
ProteomicsPathology tissue-quantitative mass spectrometry analysis to profile histone post-translational modification patterns in patient samples
Histone post-translational modifications (hPTMs) generate a complex combinatorial code that has been implicated with various pathologies, including cancer. Dissecting such a code in physiological and diseased states may be exploited for epigenetic biomarker discovery, but hPTM analysis in clinical s...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2015-10-14 | PXD002669 | Pride
Biomarker  epigenetics  ffpe  super-silac  cancer 
UnknownPathology Tissue-quantitative Mass Spectrometry Analysis to Profile Histone Post-translational Modification Patterns in Patient Samples.
Not available
S-EPMC4813706 | biostudies-literature
UnknownDevelopment of an Advanced Manufacturing Technology for Continuous Drug Substance Production.
Not available
S-EPMC12856833 | biostudies-literature
ProteomicsAlternative digestion approaches improve histone modification mapping by mass spectrometry in clinical samples
Profiling histone post-translational modifications (PTMs) in clinical samples holds great potential for the identification of epigenetic biomarkers and the discovery of novel epigenetic targets. We have recently developed a battery of mass spectrometry (MS)-based approaches to analyze histone PTMs i...
ORGANISM(S): Homo sapiens (Human) 
2010-10-08 | PXD009946 | Pride
Histone post-translational modifications Proteomics Epigenetics 
ProteomicsNSD2 is upregulated by high-risk HPV E6/E7 and modulates epithelial differentiation in HPV-associated Head and Neck Cancer
Epigenetic alterations are a key hallmark of cancer and are increasingly recognized as promising clinical biomarkers and therapeutic targets. Head and Neck Squamous Cell Carcinomas (HNSCC) are classified into two subtypes: HPV-positive (HPV+), driven by human papillomavirus (HPV) infections, and th...
ORGANISM(S): Homo sapiens (Human) 
2026-02-20 | PXD064152 | Pride
Histone post-translational modifications Head and neck cancer 
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