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ProteomicsTRIM9 and TRIM67 interactome using the BioID approach
TRIM9 and TRIM67 are two brain enriched E3 uiquitin ligases that are critical to neuronal form and function both during embryonic development and in adult-born neurons. TRIM9 and TRIM67 interact with cytoskeletal and exocytic proteins, but the full interactome is not known.Using the BioID approach w...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD021758 | Pride
Embryonic cortical neurons Orbitrap fusion lumos 
GenomicsEffect of Trim9 deficiency on adult retina
Effect of Trim9 deficiency on adult retina
PRJNA470953 | ENA
ProteomicsLoss of the E3 ubiquitin ligase Trim9 or Trim67 alters the post-synaptic density proteome
During development, neurons undergo expansive growth and shape change to achieve their mature morphology and physiological function. As cellular remodeling occurs, proteins are synthesized, transported, degraded, and recycled. As such, protein levels and localization are tightly regulated. E3 ubiqui...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-17 | PXD048045 | Pride
Synapse  post-synaptic density  trim9  trim67  e3 ubiquitin ligase 
TranscriptomicsEffect of Trim9 deficiency on adult retina
Analysis of adult retinas from tripartite motif-containing domain 9 knockouts and wild type littermates. Trim9 belongs to the TRIM family of E3 ubiquitin ligases. Results provide insight into possible roles for Trim9 in the retina.
ORGANISM(S): Mus musculus 
2018-09-12 | GSE114323 | GEO
GenomicsTRIM9-mediated resolution of neuroinflammation confers neuroprotection against ischemic stroke in mice
TRIM9-mediated resolution of neuroinflammation confers neuroprotection against ischemic stroke in mice
PRJNA472064 | ENA
TranscriptomicsDisruption of Trim9 function abrogates macrophage motility in vivo
The vertebrate immune response is comprised of multiple molecular and cellular components that interface to provide an adequate defense against pathogens. Although much is known on how individual molecules or cells respond to infection, an understanding of the whole-organism response to pathogen exp...
ORGANISM(S): Danio rerio 
2017-09-26 | GSE81317 | GEO
TranscriptomicsTRIM9-mediated resolution of neuroinflammation confers neuroprotection against ischemic stroke in mice
Excessive and unresolved neuroinflammation is part of the pathological cascade in brain injuries such as acute ischemia, as well as neurodegenerative diseases, including multiple sclerosis and Alzheimer’s disease. Particularly, timely resolution of inflammation is critical for the recovery and repai...
ORGANISM(S): Mus musculus 
2018-12-31 | GSE114652 | GEO
UnknownDisruption of Trim9 function abrogates macrophage motility in vivo.
Not available
S-EPMC6608060 | biostudies-literature
UnknownThe E3 ubiquitin ligase TRIM9 regulates synaptic function and actin dynamics.
Not available
S-EPMC10802335 | biostudies-literature
UnknownDetection of High-Risk Paraneoplastic Antibodies against TRIM9 and TRIM67 Proteins.
Not available
S-EPMC10842626 | biostudies-literature
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