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MetabolomicsMitochondrial respiration controls neoangiogenesis during wound healing and tumour growth

The vasculature represents a highly plastic compartment, capable of switching from a quiescent to an active proliferative state during angiogenesis. Metabolic reprogramming in endothelial cells (ECs) thereby is crucial to cover the increasing cellular energy demand under growth conditions. Here w...

2020-06-29 | MTBLS1764 | MetaboLights
TranscriptomicsDownregulation of three tumour suppressor genes SLC26A3, DCN and TPM1 in colorectal cancer
Despite identification of major genes and pathways involved in development of colorectal cancer (CRC) it became obvious that several steps in these pathways might be bypassed by other yet unknown genetic events that lead towards CRC. To improve our understanding of the genetic mechanisms of CRC deve...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-14010 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils
The role of myeloid cells in supporting cancer growth is well established. Most work has focused on myeloid-derived suppressor cells (MDSC) that accumulate in tumor-bearing animals, but tumor-associated neutrophils (TAN) are also known to be capable of augmenting tumor growth. However, little is kno...
ORGANISM(S): Mus musculus 
2013-01-04 | E-GEOD-43254 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Renal Cell carcinoma cell lines following global de-methylation.
Promoter region hypermethylation and transcriptional silencing is a frequent cause of tumour suppressor gene (TSG) inactivation in many types of human cancers. Functional epigenetic studies, in which gene expression is induced by treatment with demethylating agents, may identify novel genes with tum...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-22563 | biostudies-arrayexpress
ProteomicsFunctional characterisation of tumour suppressor PDCD4 reveals a previously undisclosed role in the control of cell adhesion
PDCD4 is a multifunctional RNA binding protein which has tumour suppressor function. To more fully understand how dysregulation of this protein contributes to carcinogenesis we have carried out a comprehensive analysis of the role of PDCD4 in RNA metabolism in untransformed epithelial cells. We show...
ORGANISM(S): Homo sapiens (Human) 
2024-07-31 | PXD054188 | Pride
Rna-binding Pdcd4 Nucleus Cell adhesion Translation control 
TranscriptomicsClariom S human microarray HCT116 tumour suppressor overexpression
overexpression of tumour suppressor ZAR1 in HCT116 (HCT116 wt and HCT116 delp53) colon carcinoma cell line (EYFPemtpy and ZAR1EYFP), sorted by Aria for fluorescent cells, RNA isolation
ORGANISM(S): Homo sapiens 
2020-08-27 | E-MTAB-8292 | biostudies-arrayexpress
UnknownThe clinical significance and biological function of large tumour suppressor 2 in hepatocellular carcinoma.
Not available
S-EPMC6529134 | biostudies-literature
GenomicsCBX7 is a tumour suppressor that inhibits bladder cancer
CBX7 is a tumour suppressor that inhibits bladder cancer
PRJNA664510 | ENA
ProteomicsThe TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability
Background: TP53, the most frequently mutated gene in human cancers, orchestrates a complex transcriptional program crucial for cancer prevention. While certain TP53-dependent genes have been extensively studied, others, like the recently identified RNF144B, remained poorly understood. This E3 ubiqu...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-23 | PXD051459 | Pride
Tumor suppressor Genomic instability Cancer Aneuploidy 
UnknownPutative tumour suppressor gene necdin is hypermethylated and mutated in human cancer.
Not available
S-EPMC3619261 | biostudies-literature
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