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TranscriptomicsA network of transcriptional repression specifies muscle fibre type in the zebrafish embryo
The zebrafish u-boot (ubo) gene encodes the transcription factor Prdm1, which is essential for the specification of the primary slow twitch muscle fibres that derive from adaxial cells. Here we show that Prdm1 executes this function by acting as a transcriptional repressor. Expression of the slow tw...
ORGANISM(S): Danio rerio 
2010-05-25 | E-GEOD-10883 | biostudies-arrayexpress
UnknownNeed for speed: Human fast-twitch mitochondria favor power over efficiency.
Not available
S-EPMC10788296 | biostudies-literature
TranscriptomicsTranscription profiling of skeletal muscle from wild type and PGC-1 beta transgenic mice
Skeletal muscle must perform a wide range of kinds of work, and different fiber types have evolved to accommodate these different tasks. The attributes of fibers are determined in large part by the coordinated regulation of oxidative capacity, as reflected by mitochondrial content, and the specific...
ORGANISM(S): Mus musculus 
2007-04-02 | E-MEXP-939 | biostudies-arrayexpress
UnknownGenerating fast-twitch myotubes in vitro with an optogenetic-based, quantitative contractility assay.
Not available
S-EPMC10427763 | biostudies-literature
ProteomicsIntegrated Fibre-Specific Methylome and Proteome Profiling of Human Skeletal Muscle Across Males and Females with Fibre-Type Deconvolution.
We simultaneously extracted DNA and protein from >200 single fibres per participant (7 males, 5 females) to directly compare methylome and proteome profiles of Type I and Type II human skeletal muscle fibres. Using the EPICv2 array and LC-MS/MS, we identified 5,689 robust DMRs (FDR <0.001) and 338 D...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD066393 | Pride
Human skeletal muscle  muscle fibres  type i (slow-twitch)  type ii (fast-twitch)  dna methylation  proteome  lc-ms/ms  epicv2 infinium array  deconvolution  myometh  myotype. 
MetabolomicsImpacts of the Callipyge mutation on ovine plasma metabolites
The ovine Callipyge mutation causes postnatal muscle hypertrophy localized to the pelvic limbs and torso, as well as body leanness. The mechanism underpinning enhanced muscle mass is unclear, as is the systemic impact of the mutation. To investigate potential systemic effects of the mutation, 1H NMR...
2015-01-31 | MTBLS77 | MetaboLights
TranscriptomicsEffect of endurance training on expression signatures of mouse type I and type IIb myofibers
Skeletal muscle myofibers, categorized into slow-twitch (type I) and fast-twitch (type II) fibers based on myosin heavy chain (MHC) isoforms, exhibit varying fatigue resistance and metabolic reliance. Type I myofibers are fatigue-resistant with high mitochondrial density and oxidative metabolism, wh...
ORGANISM(S): Mus musculus 
2024-12-31 | GSE244547 | GEO
UnknownCycle training increased GLUT4 and activation of mammalian target of rapamycin in fast twitch muscle fibers.
Not available
S-EPMC2796589 | biostudies-literature
UnknownMyokine BDNF highly expressed in Type I fibers inhibits the differentiation of myotubes into Type II fibers.
Not available
S-EPMC11557626 | biostudies-literature
GenomicsEffect of endurance training on expression signatures of mouse type I and type IIb myofibers
Effect of endurance training on expression signatures of mouse type I and type IIb myofibers
PRJNA1023534 | ENA
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