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GenomicsThe human U5 snRNP assembly factor, AAR2, regulates gene expression dependent on the PRPF8 protein
The human U5 snRNP assembly factor, AAR2, regulates gene expression dependent on the PRPF8 protein
PRJNA758575 | ENA
TranscriptomicsThe human U5 snRNP assembly factor, AAR2, regulates gene expression dependent on the PRPF8 protein
Small nuclear ribonucleoprotein complexes (snRNPs) represent the main subunits of the spliceosome. While the assembly of snRNP core particles has been well characterized, the incorporation of snRNP-specific proteins and the mechanisms of snRNP recycling after splicing are less well characterized. Fu...
ORGANISM(S): Homo sapiens 
2025-08-16 | GSE182977 | GEO
UnknownThe human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.
Not available
S-EPMC1370748 | biostudies-literature
ProteomicsR2TP_SILAC_FLAG-MS - R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein
The R2TP/Prefoldin-like (R2TP/PFDL) complex is a cochaperone complex involved in the assembly of a number of critical protein complexes. Here we use stable isotope labeling with amino acids in cell culture (SILAC) and FLAG tag affinity purification coupled to mass spectrometry to assess whether siRN...
ORGANISM(S): Homo sapiens (Human) 
2017-11-02 | PXD006199 | Pride
Human Lc-msms Tsc complex Affinity purification U5 snrnp Znhit2 Hek 293 Flag 
UnknownTSSC4 is a component of U5 snRNP that promotes tri-snRNP formation.
Not available
S-EPMC8206348 | biostudies-literature
UnknownStructural basis for dual roles of Aar2p in U5 snRNP assembly.
Not available
S-EPMC3605466 | biostudies-literature
UnknownStructure of the human 20S U5 snRNP.
Not available
S-EPMC11102862 | biostudies-literature
UnknownAssembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.
Not available
S-EPMC5461031 | biostudies-literature
UnknownMechanism for Aar2p function as a U5 snRNP assembly factor.
Not available
S-EPMC3182018 | biostudies-literature
UnknownIdentification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.
Not available
S-EPMC5672036 | biostudies-literature
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