Sort   by:  
 Page size 
ProteomicsType I interferon/STAT1 signaling negative feedback regulates UBE2M-mediated antiviral innate immunity
To identify potential proteins involved in RIG-I regulation, we pulled down RIG-I from HEK293T or NIH-3T3 cells overexpressing RIG-I, and the RIG-I-bound proteins were then analyzed by mass spectrometry (MS).
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-01-30 | PXD039071 | Pride
Hek293t nih-3t3 lc-msms rig-i ube2m 
ProteomicsRequirement of Rbx1 Cullin-RING ligase E3 and Ube2m neddylation E2 in the maintenance of the fitness of Treg cells
the Ube2m-Rbx1 axis is required for the maintenance of homeostasis and functions of Treg cells; and Rbx1 has Ube2m-independent roles in the fitness of Treg cells, suggesting a layer of complexity in neddylation activation of CRLs.
ORGANISM(S): Mus Musculus 
2021-12-03 | PXD030144 |
GenomicsTranscriptome data of wt, Rbx1- or Ube2m- deficient Treg cells from mice
Transcriptome data of wt, Rbx1- or Ube2m- deficient Treg cells from mice
PRJNA792577 | ENA
TranscriptomicsTranscriptome data of wt, Rbx1- or Ube2m- deficient Treg cells from mice
Cullin-RING Ligases (CRLs), upon activation by neddylation, play the key roles in regulating many biological processes. However, how CRL-neddylation regulates the function of Treg cells remains elusive. Here we show that mice with Treg-specific deletion of Rbx1, a RING component of CRLs required for...
ORGANISM(S): Mus musculus 
2021-12-28 | GSE192664 | GEO
TranscriptomicsE2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Ubiquitin and ubiquitin-like proteins (UBLs) are directed to targets by cascades of E1, E2, and E3 enzymes. The largest ubiquitin E3 subclass consists of cullin-RING ligases (CRLs), which contain one each of several cullins (CUL1, -2, -3, -4, or -5) and RING proteins (RBX1 or -2). CRLs are activated...
ORGANISM(S): Mus musculus 
2009-03-23 | E-GEOD-14088 | biostudies-arrayexpress
GenomicsTranscriptome data of Foxp3-Cre, Ube2m&Ube2f-deficient Treg cells from mice
Transcriptome data of Foxp3-Cre, Ube2m&Ube2f-deficient Treg cells from mice
PRJNA995532 | ENA
UnknownUBE2M promotes cell proliferation via the β-catenin/cyclin D1 signaling in hepatocellular carcinoma.
Not available
S-EPMC7041726 | biostudies-literature
UnknownInhibition of the neddylation E2 enzyme UBE2M in macrophages protects against E. coli-induced sepsis.
Not available
S-EPMC11780929 | biostudies-literature
UnknownInactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases.
Not available
S-EPMC4099125 | biostudies-literature
GenomicsNAE1/UBA3-UBE2M are E1 and E2 Enzymes for the Urm1 Modification in Human Cells
NAE1/UBA3-UBE2M are E1 and E2 Enzymes for the Urm1 Modification in Human Cells
PRJNA1307993 | ENA
Sort   by:  
 Page size